GTR Home > Conditions/Phenotypes > Psoriatic arthritis, susceptibility to

Summary

Psoriasis (177900) is a chronic inflammatory skin disease that may have an autoimmune basis. The disorder has a strong but complex genetic basis, with a concordance rate of 50 to 70% among monozygotic twins. Psoriatic arthritis affects more than 10% of patients with psoriasis and, in most cases, there is an association between the severity of the arthritis and the skin involvement (Gudjonsson et al., 2002). [from OMIM]

Associated genes

  • Also known as: DAMA-25N12.13-004, LT, TNFB, TNFSF1, LTA
    Summary: lymphotoxin alpha

  • Also known as: ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, NOD2
    Summary: nucleotide-binding oligomerization domain containing 2

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