GTR Home > Conditions/Phenotypes > Mycobacterium tuberculosis, susceptibility to

Summary

Mycobacterium tuberculosis latently infects approximately one-third of humanity and is comparable only to human immunodeficiency virus (HIV; see 609423) as a leading infectious cause of mortality worldwide. Obstacles for controlling TB infection include lengthy treatment regimens of 6 to 9 months, drug resistance, lack of a highly efficacious vaccine, and incomplete understanding of the factors that control infectivity and disease progression. Although only 10% of individuals infected with M. tuberculosis develop active disease, the immune responses associated with TB susceptibility or resistance are not known. In addition, it is not known why some individuals have disseminated TB that spreads to the meninges and central nervous system, while most people have localized disease in the lungs. A number of studies suggest that host genetic factors influence susceptibility and resistance to TB (review by Berrington and Hawn, 2007). [from OMIM]

Available tests

5 tests are in the database for this condition. Compare labs offering these tests.

Check Associated genes for additional relevant tests.

Associated genes

  • Also known as: GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, CCL2
    Summary: chemokine (C-C motif) ligand 2

  • Also known as: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209
    Summary: CD209 molecule

  • Also known as: BACTS2, CIS, CIS-1, G18, SOCS, CISH
    Summary: cytokine inducible SH2-containing protein

  • Also known as: IFG, IFI, IFNG
    Summary: interferon, gamma

  • Also known as: RP3-503F13.3, CD119, IFNGR, IMD27A, IMD27B, IFNGR1
    Summary: interferon gamma receptor 1

  • Also known as: IFI1, IRGM1, LRG-47, LRG47, IRGM
    Summary: immunity-related GTPase family, M

  • Also known as: BMIQ9, MC3, MC3-R, OB20, OQTL, MC3R
    Summary: melanocortin 3 receptor

  • Also known as: LSH, NRAMP, NRAMP1, SLC11A1
    Summary: solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1

  • Also known as: IFI41, IFI75, IPR1, VODI, SP110
    Summary: SP110 nuclear body protein

  • Also known as: BACTS1, Mal, MyD88-2, wyatt, TIRAP
    Summary: toll-interleukin 1 receptor (TIR) domain containing adaptor protein

  • Also known as: CD282, TIL4, TLR2
    Summary: toll-like receptor 2

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