GTR Home > Conditions/Phenotypes > Mesangiocapillary glomerulonephritis, type II


Dense deposit disease is a condition that primarily affects kidney (renal) function. The signs and symptoms usually appear between the ages of 5 and 15, although they can also begin in adulthood. The major features of dense deposit disease result from kidney malfunction. They most often include a loss of protein in the urine (proteinuria), the presence of blood in the urine (hematuria), reduced amounts of urine, low levels of protein in the blood, and swelling in many areas of the body. The kidney problems associated with this disorder tend to worsen over time, and about half of affected individuals develop end-stage renal disease (ESRD) within 10 years after symptoms appear. ESRD is a life-threatening condition that prevents the kidneys from filtering fluids and waste products from the body effectively. Dense deposit disease can also be associated with other conditions unrelated to kidney function. For example, the disorder can ... occur with acquired partial lipodystrophy, a condition characterized by a lack of fatty (adipose) tissue under the skin in the upper part of the body. Additionally, some people with dense deposit disease develop a buildup of yellowish deposits called drusen in the light-sensitive tissue at the back of the eye (the retina). These deposits usually appear in childhood or adolescence and can cause vision problems later in life. Dense deposit disease was previously known as membranoproliferative glomerulonephritis type II (MPGN II). However, recent insights into the underlying cause of the disorder suggest that it is unlikely to be a true form of membranoproliferative glomerulonephritis. Nevertheless, many resources still use the term MPGN II to refer to dense deposit disease. [from GHR] more

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