GTR Home > Conditions/Phenotypes > Pseudoprimary hyperaldosteronism

Summary

Liddle syndrome is an inherited form of high blood pressure (hypertension). This condition is characterized by severe hypertension that begins unusually early in life, often in childhood, although some affected individuals are not diagnosed until adulthood. Some people with Liddle syndrome have no additional signs or symptoms, especially in childhood. Over time, however, untreated hypertension can lead to heart disease or stroke, which may be fatal. In addition to hypertension, affected individuals can have low levels of potassium in the blood (hypokalemia). Signs and symptoms of hypokalemia include muscle weakness or pain, fatigue, constipation, or heart palpitations. The shortage of potassium can also raise the pH of the blood, a condition known as metabolic alkalosis. [from GHR]

Available tests

26 tests are in the database for this condition. Compare labs offering these tests.

Check Associated genes and Related conditions for additional relevant tests.

Associated genes

  • Also known as: hCG_23853, BESC1, ENaCb, ENaCbeta, SCNEB, SCNN1B
    Summary: sodium channel, non-voltage-gated 1, beta subunit

  • Also known as: BESC3, ENaCg, ENaCgamma, PHA1, SCNEG, SCNN1G
    Summary: sodium channel, non-voltage-gated 1, gamma subunit

Clinical features

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  • Hypokalemia
  • Muscle weakness
  • Irregular heart beat
  • Hypertension
  • Hypoaldosteronism
  • Constipation
  • Renal insufficiency
  • Nephropathy
  • Hypokalemic alkalosis
  • Cerebral ischemia
  • Decreased circulating renin level
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