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    Uba1y ubiquitin-activating enzyme, Chr Y [ Mus musculus (house mouse) ]

    Gene ID: 22202, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Uba1yprovided by MGI
    Official Full Name
    ubiquitin-activating enzyme, Chr Yprovided by MGI
    Primary source
    MGI:MGI:98891
    See related
    Ensembl:ENSMUSG00000069053 AllianceGenome:MGI:98891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sby; Ube-2; Ube1y; Ube1ay; Ube1y1; A1s9Y-1; Ube1y-1
    Summary
    Enables ubiquitin activating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in adrenal gland; brain; liver; and testis. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 6.5) See more
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    Genomic context

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    Location:
    Y; Ypter
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (818612..843684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (818612..843684)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48292 Neighboring gene STARR-seq mESC enhancer starr_48293 Neighboring gene zinc finger protein 1, Y-linked Neighboring gene ras homolog A translocated to the Y, pseudogene 3 Neighboring gene lysine demethylase 5D Neighboring gene STARR-seq mESC enhancer starr_48294

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Ciechanover A, et al. Cell, 1984 May. PMID 6327060
    2. Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Finley D, et al. Cell, 1984 May. PMID 6327059
    3. Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y. Mitchell MJ, et al. Nature, 1992 Oct 8. PMID 1406968
    4. The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenes. Lévy N, et al. Mamm Genome, 2000 Feb. PMID 10656933
    5. The ubiquitin-proteasome pathway: on protein death and cell life. Ciechanover A. EMBO J, 1998 Dec 15. PMID 9857172, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like modifier-activating enzyme 1 Y
    Names
    ubiquitin-activating enzyme E1 Y
    ubiquitin-activating enzyme E1, Chr Y 1
    NP_001343972.1
    XP_030107423.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357043.1 → NP_001343972.1  ubiquitin-like modifier-activating enzyme 1 Y

      Status: VALIDATED

      Source sequence(s)
      AC139318, AF150963
      Consensus CDS
      CCDS30540.1
      UniProtKB/Swiss-Prot
      P31254, Q60639, Q8CDH7, Q9QYS4, Q9QZX2
      Related
      ENSMUSP00000140543.2, ENSMUST00000190013.7
      Conserved Domains (1) summary
      TIGR01408
      Location:48 → 1055
      Ube1; ubiquitin-activating enzyme E1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      818612..843684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251563.1 → XP_030107423.1  ubiquitin-like modifier-activating enzyme 1 Y isoform X1

      Conserved Domains (1) summary
      TIGR01408
      Location:48 → 1084
      Ube1; ubiquitin-activating enzyme E1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011667.2: Suppressed sequence

      Description
      NM_011667.2: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31254.2 GenPept UniProtKB/Swiss-Prot:P31254

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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