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    Cct5 chaperonin containing TCP1 subunit 5 [ Mus musculus (house mouse) ]

    Gene ID: 12465, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cct5provided by MGI
    Official Full Name
    chaperonin containing TCP1 subunit 5provided by MGI
    Primary source
    MGI:MGI:107185
    See related
    Ensembl:ENSMUSG00000022234 AllianceGenome:MGI:107185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccte; TCPE; mKIAA0098; CCT-epsilon; TCP-1-epsilon
    Summary
    Predicted to enable several functions, including G-protein beta-subunit binding activity; beta-tubulin binding activity; and mRNA binding activity. Acts upstream of or within binding activity of sperm to zona pellucida and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in 1st branchial arch mandibular component and mandible primordium. Orthologous to human CCT5 (chaperonin containing TCP1 subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 143.9), placenta adult (RPKM 109.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B2; 15 13.02 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31590946..31601992, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31590800..31601846, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 49208 Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene STARR-seq mESC enhancer starr_38292 Neighboring gene carboxymethylenebutenolidase homolog Neighboring gene STARR-positive B cell enhancer ABC_E4130 Neighboring gene ATP synthase C subunit lysine N-methyltransferase Neighboring gene predicted gene, 32383

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia. Bouhouche A, et al. J Med Genet, 2006 May. PMID 16399879, Free PMC Article
    2. Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms. Fink JK. Acta Neuropathol, 2013 Sep. PMID 23897027, Free PMC Article
    3. Eukaryotic type II chaperonin CCT interacts with actin through specific subunits. Llorca O, et al. Nature, 1999 Dec 9. PMID 10604479
    4. Two proteins, a goldfish 20S proteasome subunit and the protein interacting with 26S proteasome, change in the meiotic cell cycle. Tokumoto M, et al. Eur J Biochem, 2000 Jan. PMID 10601855
    5. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. Yanaka N, et al. J Biol Chem, 2000 May 19. PMID 10747865

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Chaperone Protein Cct5 is Essential for Hematopoietic Stem Cell Maintenance.
      Title: The Chaperone Protein Cct5 is Essential for Hematopoietic Stem Cell Maintenance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 

    General protein information

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    Preferred Names
    T-complex protein 1 subunit epsilon
    Names
    chaperonin containing Tcp1, subunit 5 (epsilon)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348035.1 → NP_001334964.1  T-complex protein 1 subunit epsilon isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC137842, BC094427, BY579491, CX238090
      UniProtKB/Swiss-Prot
      P80316
      Conserved Domains (1) summary
      cd03339
      Location:1 → 497
      TCP1_epsilon; TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

    2. NM_007637.3 → NP_031663.1  T-complex protein 1 subunit epsilon isoform 1

      See identical proteins and their annotated locations for NP_031663.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC094427, BY579491, CJ086704
      Consensus CDS
      CCDS27411.1
      UniProtKB/Swiss-Prot
      P80316, Q3TIE0, Q3U530, Q3UCU4, Q3UJK9, Q3UWA9, Q542K3, Q6ZQJ1
      Related
      ENSMUSP00000022842.9, ENSMUST00000022842.16
      Conserved Domains (2) summary
      cd03339
      Location:10 → 535
      TCP1_epsilon; TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:44 → 533
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      31590946..31601992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80316.1 GenPept UniProtKB/Swiss-Prot:P80316

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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