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    CDH2 cadherin 2 [ Gallus gallus (chicken) ]

    Gene ID: 414745, updated on 3-Apr-2024

    Summary

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    Symbol
    CDH2provided by CGNC
    Full Name
    cadherin 2provided by CGNC
    Primary source
    CGNC:11259
    See related
    Ensembl:ENSGALG00010005621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    cadherin-2
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (104411911..104526394, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (104470744..104585166, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC769098 Neighboring gene uncharacterized LOC124417748 Neighboring gene uncharacterized LOC112531839 Neighboring gene uncharacterized LOC101749116

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of N-cadherin on neuronal migration during chicken optic tectum development. Yang C, et al. Histochem Cell Biol, 2019 Mar. PMID 30250974
    2. N-cadherin locks left-right asymmetry by ending the leftward movement of Hensen's node cells. Mendes RV, et al. Dev Cell, 2014 Aug 11. PMID 25117685
    3. Identification of a novel intermediate filament-linked N-cadherin/gamma-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cells. Leonard M, et al. Dev Biol, 2008 Jul 15. PMID 18514185, Free PMC Article
    4. Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. Lambert M, et al. J Cell Biol, 2002 Apr 29. PMID 11970959, Free PMC Article
    5. Isolation and characterization of the promoter region of the chicken N-cadherin gene. Li B, et al. Gene, 1997 May 20. PMID 9210582

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly.
      Title: Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly.
    2. The results reveal that the knockdown of N-cadherin mainly affects the length of axons and formation of multipolar neurons in the development of the chicken optic tectum, which eventually results in the inhibition of neuronal migration.
      Title: Effects of N-cadherin on neuronal migration during chicken optic tectum development.
    3. we demonstrate that the balance of Ecad and Ncad is dependent upon the availability of beta-catenin proteins, and that alteration of either classical cadherin modifies the proportions of the neural crest and neuroectodermal cells that are specified
      Title: A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices.
    4. in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM and exhibits a striking complementary pattern to N-cadherin
      Title: PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin-dependent adhesion.
    5. N-cadherin stops the leftward cell movements and that this termination is an essential step in the establishment of left-right asymmetry
      Title: N-cadherin locks left-right asymmetry by ending the leftward movement of Hensen's node cells.
    6. These results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors.
      Title: Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
    7. Inhibition of ADAM10 can inhibit Pax6 expression and N-cadherin ectodomain shedding in retinal cells, possibly affecting neurite outgrowth and ganglion cell differentiation.
      Title: ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina.
    8. Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.
      Title: N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
    9. These findings suggest that ligand-selective mechanotransduction may supersede differences in cadherin binding affinities in regulating intercellular contacts.
      Title: Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.
    10. overexpressing N-cadherin on axons prevents the formation of the lateral funiculus and the spinocerebellar tract
      Title: Axon sorting within the spinal cord marginal zone via Robo-mediated inhibition of N-cadherin controls spinocerebellar tract formation.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intercalated disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-2
    Names
    N-cadherin
    cadherin 2, type 1, N-cadherin (neuronal)
    neural cadherin
    neural calcium-dependent cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001615.2 → NP_001001615.1  cadherin-2 precursor

      See identical proteins and their annotated locations for NP_001001615.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000043, X07277
      UniProtKB/Swiss-Prot
      P10288, Q90630
      UniProtKB/TrEMBL
      A0A8V0XQ13
      Related
      ENSGALP00010007990.1, ENSGALT00010013463.1
      Conserved Domains (5) summary
      cd11304
      Location:278 → 383
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam00028
      Location:615 → 707
      Cadherin; Cadherin domain
      pfam01049
      Location:765 → 908
      Cadherin_C; Cadherin cytoplasmic region
      pfam08758
      Location:36 → 126
      Cadherin_pro; Cadherin prodomain like
      cl09101
      Location:168 → 268
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      104411911..104526394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040677263.2 → XP_040533197.1  cadherin-2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2UGT3, A0A8V0XQ13
      Related
      ENSGALP00010007983.1, ENSGALT00010013455.1
      Conserved Domains (3) summary
      cd11304
      Location:216 → 321
      Cadherin_repeat; Cadherin tandem repeat domain
      smart01055
      Location:2 → 62
      Cadherin_pro; Cadherin prodomain like
      cl28889
      Location:106 → 206
      CA_like; Cadherin repeat-like domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      104470744..104585166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910581.1 → XP_046766537.1  cadherin-2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2UGT3

    2. XM_046910580.1 → XP_046766536.1  cadherin-2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q2UGT3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10288.1 GenPept UniProtKB/Swiss-Prot:P10288

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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