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    BRK1 BRICK1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816795, updated on 7-Sep-2023

    Summary

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    Gene symbol
    BRK1
    Gene description
    BRICK1
    Primary source
    Araport:AT2G22640
    Locus tag
    AT2G22640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBRK1; BRICK1; HSPC300; T9I22.8; T9I22_8
    Summary
    Component of the WAVE protein complex which act as activators of ARP2/3 complex involved in actin nucleation. Required for trichome morphogenesis. Required for accumulation of SCAR1 protein in vivo. Selectively stabilizes SCAR2.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (9622997..9624335)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AGAMOUS-like 17 Neighboring gene FAD-dependent oxidoreductase family protein Neighboring gene DNA-binding protein, putative (duplicated DUF1399)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis BRICK1/HSPC300 is an essential WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2. Le J, et al. Curr Biol, 2006 May 9. PMID 16584883
    2. BRICK1 is required for apical cell growth in filaments of the moss Physcomitrella patens but not for gametophore morphology. Perroud PF, et al. Plant Cell, 2008 Feb. PMID 18263777, Free PMC Article
    3. The IRREGULAR TRICHOME BRANCH loci regulate trichome elongation in Arabidopsis. Zhang X, et al. Plant Cell Physiol, 2005 Sep. PMID 16043432
    4. Plasma membrane-associated SCAR complex subunits promote cortical F-actin accumulation and normal growth characteristics in Arabidopsis roots. Dyachok J, et al. Mol Plant, 2008 Nov. PMID 19825598
    5. BRICK1/HSPC300 functions with SCAR and the ARP2/3 complex to regulate epidermal cell shape in Arabidopsis. Djakovic S, et al. Development, 2006 Mar. PMID 16481352

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BRK1 is required for accumulation of SCAR1 protein in vivo, potentially explaining the apparently essential role of BRK1 in ARP2/3 complex function
      Title: BRICK1/HSPC300 functions with SCAR and the ARP2/3 complex to regulate epidermal cell shape in Arabidopsis.
    2. member of the "distorted group" of trichome morphology mutants and a critical WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2
      Title: Arabidopsis BRICK1/HSPC300 is an essential WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127829.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament polymerization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within actin nucleation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCAR complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRICK1
    NP_179849.2
    • BRICK1 (BRK1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9622997..9624335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127829.3 → NP_179849.2  BRICK1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179849.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94JY4, Q9ZQ49
      UniProtKB/TrEMBL
      A0A178VTW7, A0A5S9X0F6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94JY4.1

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