SMC2 condensin subunit SMC2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: SMC2
Gene description: condensin subunit SMC2
Primary source: SGD:S000001927
Locus tag: YFR031C
See related: AllianceGenome:SGD:S000001927
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATP binding activity; DNA binding activity; and chromatin binding activity. Contributes to ATP hydrolysis activity. Involved in chromosome organization and negative regulation of meiotic DNA double-strand break formation. Located in mitochondrion. Part of condensin complex. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Title: Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
S. cerevisiae Smc2-Smc4 dimers adopt a variety of conformations.
Title: Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.
Contribution of condensin binding sites in securing mitotic stability of the minichromosomes.
Title: [Functional characteristics of the individual genomic condensin binding sites of Saccharomyces cerevisiae using minichromosome mitotic segregation stability model].
Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling
Title: The Saccharomyces cerevisiae Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling.
The SMC2 is involved in several aspects of chromatin dynamics and DNA recombitional repair.
Title: Multiple roles of Condensins: a complex story.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA secondary structure binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of meiotic DNA double-strand break formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA chromatin condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA gene clustering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_116687.1

Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain