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    IMD2 IMP dehydrogenase IMD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856626, updated on 13-Apr-2024

    Summary

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    Gene symbol
    IMD2
    Gene description
    IMP dehydrogenase IMD2
    Primary source
    SGD:S000001259
    Locus tag
    YHR216W
    See related
    AllianceGenome:SGD:S000001259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PUR5
    Summary
    Enables chromatin binding activity. Predicted to be involved in GTP biosynthetic process. Located in chromatin and cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (554396..555967)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene acid phosphatase PHO12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic basis of mycotoxin susceptibility differences between budding yeast isolates. Quispe X, et al. Sci Rep, 2017 Aug 23. PMID 28835621, Free PMC Article
    2. Properties of an intergenic terminator and start site switch that regulate IMD2 transcription in yeast. Jenks MH, et al. Mol Cell Biol, 2008 Jun. PMID 18426909, Free PMC Article
    3. Dissection of the molecular basis of mycophenolate resistance in Saccharomyces cerevisiae. Jenks MH, et al. Yeast, 2005 Nov. PMID 16278936
    4. Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Escobar-Henriques M, et al. Mol Cell Biol, 2003 Sep. PMID 12917348, Free PMC Article
    5. Metabolic regulation of IMD2 transcription and an unusual DNA element that generates short transcripts. Kopcewicz KA, et al. Mol Cell Biol, 2007 Apr. PMID 17296737, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IMD2, located near the boundary of heterochromatin regions, is regulated by multiple HAT-related factors.
      Title: IMD2, located near the boundary of heterochromatin regions, is regulated by multiple HAT-related factors.
    2. Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1
      Title: Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1.
    3. analysis of an intergenic terminator and start site switch that regulate IMD2 transcription in S. cerevisiae
      Title: Properties of an intergenic terminator and start site switch that regulate IMD2 transcription in yeast.
    4. These findings support a model in which intergenic short transcripts emanating from upstream of the IMD2 promoter are terminated by a polyadenylation/terminator-like signal embedded within the IMD2 transcription start site.
      Title: Metabolic regulation of IMD2 transcription and an unusual DNA element that generates short transcripts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IMP dehydrogenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GTP biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IMP dehydrogenase IMD2
    NP_012088.3
    • Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      554396..555967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179347.3 → NP_012088.3  TPA: IMP dehydrogenase IMD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012088.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLH1, P38697
      UniProtKB/TrEMBL
      A0A8H4F9Z9, C8Z7M4, G2WDJ8
      Conserved Domains (1) summary
      PTZ00314
      Location:21 → 518
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38697.1

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