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    STE18 Ste18p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853548, updated on 3-Mar-2024

    Summary

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    Gene symbol
    STE18
    Gene description
    Ste18p
    Primary source
    SGD:S000003846
    Locus tag
    YJR086W
    See related
    AllianceGenome:SGD:S000003846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables G-protein beta-subunit binding activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in cytoplasm and plasma membrane. Part of Cdc24p-Far1p-Gbetagamma complex; G-protein beta/gamma-subunit complex; and heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See STE18 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (586068..586400)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tmh11p Neighboring gene Emc2p Neighboring gene survivin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C-terminal tail preceding the CAAX box of a yeast G protein gamma subunit is dispensable for receptor-mediated G protein activation in vivo. Chinault SL, et al. J Biol Chem, 2003 Jun 6. PMID 12665529
    2. Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein gamma subunit. Grishin AV, et al. Mol Cell Biol, 1994 Jul. PMID 8007961, Free PMC Article
    3. Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylation. Finegold AA, et al. Science, 1990 Jul 13. PMID 1695391
    4. Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association. Chernova TA, et al. Int J Mol Sci, 2020 Jul 16. PMID 32708832, Free PMC Article
    5. Construction of a novel detection system for protein-protein interactions using yeast G-protein signaling. Fukuda N, et al. FEBS J, 2009 May. PMID 19476500

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
      Title: Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
    2. phosphorylation of the yeast Ggamma subunit (Ste18), together with Fus3 docking on Ste5, controls the rate and stability of Ste5/plasma membrane association.
      Title: Negative Feedback Phosphorylation of Gγ Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast.
    3. Data show that the pheromone-responsive G protein subunits beta/gamma (Gbetagamma; STE4/STE18) dimer promotes the polarization of the pheromone receptor by interacting with casein kinases 1 or 2 (Yck1/2) and locally inhibiting receptor phosphorylation.
      Title: Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation.
    4. These results indicate that chemoattractant-induced cell polarization requires continuous receptor-Galphabetagamma communication but not modulation of MAP kinase signaling.
      Title: Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc24p-Far1p-Gbetagamma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of G-protein beta/gamma-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of G-protein beta/gamma-subunit complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of G-protein beta/gamma-subunit complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ste18p
    NP_012619.1
    • G protein gamma subunit; forms dimer with Ste4p to activate mating signaling pathway, heterotrimer with Gpa1p, Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; N-terminal phosphorylation of Ste18p functions synergistically with Fus3p docking site on Ste5p to restrict Ste5p plasma membrane recruitment and signaling; combinatorial phosphorylation at S3 and S7, by pheromone and pH stress, modulates Ste18p structure, Fus3p activation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      586068..586400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181743.1 → NP_012619.1  TPA: Ste18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWQ5, P18852
      UniProtKB/TrEMBL
      A0A6A5PT44, A6ZQ42, B3LQH1, C7GMC0, C8ZBN2, G2WH89, N1P161
      Conserved Domains (1) summary
      pfam00631
      Location:29 → 91
      G-gamma; GGL domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18852.1

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