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    ARN1 siderophore transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856345, updated on 13-Apr-2024

    Summary

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    Gene symbol
    ARN1
    Gene description
    siderophore transporter
    Primary source
    SGD:S000001032
    Locus tag
    YHL040C
    See related
    AllianceGenome:SGD:S000001032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables siderophore transmembrane transporter activity. Involved in siderophore transport. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (19088..20971, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene protein-lysine N-methyltransferase Neighboring gene Cbp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae. Moore RE, et al. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12721368, Free PMC Article
    2. Identification and substrate specificity of a ferrichrome-type siderophore transporter (Arn1p) in Saccharomyces cerevisiae. Heymann P, et al. FEMS Microbiol Lett, 2000 May 15. PMID 10802175
    3. A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1. Kim Y, et al. EMBO J, 2005 Mar 9. PMID 15719020, Free PMC Article
    4. Ferrichrome induces endosome to plasma membrane cycling of the ferrichrome transporter, Arn1p, in Saccharomyces cerevisiae. Kim Y, et al. EMBO J, 2002 Jul 15. PMID 12110576, Free PMC Article
    5. GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae. Kim Y, et al. Mol Biol Cell, 2007 May. PMID 17344478, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphatidylserine is involved in the ferrichrome-induced plasma membrane trafficking of Arn1 in Saccharomyces cerevisiae
      Title: Phosphatidylserine is involved in the ferrichrome-induced plasma membrane trafficking of Arn1 in Saccharomyces cerevisiae.
    2. Ubiquitin binding by Gga2 was not required for the trans-Golgi network to endosome trafficking of Arn1, but it was required for sorting of Arn1 into the vacuole.
      Title: Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole.
    3. the carboxyl terminus of Arn1p contains a receptor domain that controls the intracellular trafficking of the transporter
      Title: A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1.
    4. clathrin adaptor Gga2 and ubiquitination by the Rsp5 ubiquitin ligase are required for trafficking of Arn1
      Title: GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables siderophore-iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables siderophore-iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    siderophore transporter
    NP_011823.1
    • ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      19088..20971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179120.1 → NP_011823.1  TPA: siderophore transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKS9, P38731
      UniProtKB/TrEMBL
      A0A8H4BZD2, A6ZSL1, B3LS81, C7GRT3, G2WF26, N1P1F6
      Conserved Domains (1) summary
      cd17322
      Location:74 → 586
      MFS_ARN_like; Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38731.1

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