U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ppk polyphosphate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946971, updated on 4-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    ppk
    Gene description
    polyphosphate kinase
    Primary source
    ASAP:ABE-0008235
    Locus tag
    b2501
    See related
    ECOCYC:EG11510
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2497
    Summary
    The role of polyphosphate (poly(Pi)) in Escherichia coli is still not fully understood; it may function in energy storage. [More information is available at EcoCyc: EG11510].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2623044..2625110)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uracil phosphoribosyltransferase Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene exopolyphosphatase Neighboring gene cyclic di-GMP phosphodiesterase PdeF

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations in Escherichia coli Polyphosphate Kinase That Lead to Dramatically Increased In Vivo Polyphosphate Levels. Rudat AK, et al. J Bacteriol, 2018 Mar 15. PMID 29311274, Free PMC Article
    2. Polyphosphate kinase 1 is required for the pathogenesis process of meningitic Escherichia coli K1 (RS218). Peng L, et al. Future Microbiol, 2012 Mar. PMID 22393893
    3. Phosphate-enhanced stationary-phase fitness of Escherichia coli is related to inorganic polyphosphate level. Schurig-Briccio LA, et al. J Bacteriol, 2009 Jul. PMID 19376858, Free PMC Article
    4. Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis. Zhu Y, et al. EMBO Rep, 2005 Jul. PMID 15947782, Free PMC Article
    5. Crystallization and characterization of polyphosphate kinase from Escherichia coli. Zhu Y, et al. Biochem Biophys Res Commun, 2003 Jun 13. PMID 12767929

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using Escherichia coli as a model organism, we have identified the first known mutations in polyP kinase that lead to increases in cellular polyP content.
      Title: Mutations in Escherichia coli Polyphosphate Kinase That Lead to Dramatically Increased In Vivo Polyphosphate Levels.
    2. These results indicate that ppk1 plays an important role in stress adaptation and virulence in meningitic E. coli K1 strain E44.
      Title: Polyphosphate kinase 1 is required for the pathogenesis process of meningitic Escherichia coli K1 (RS218).
    3. N-terminus verified by Edman degradation on mature peptide
      Title: The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein.
    4. Ppk is required for the increased rate of growth-dependent mutations produced by Pol IV overexpression; results suggest Ppk is affecting the activity of Pol IV in a manner that is independent of any previously known factors that regulate this polymerase
      Title: Polyphosphate kinase regulates error-prone replication by DNA polymerase IV in Escherichia coli.
    5. crystal structures of full-length Escherichia coli PPK and its complex with AMPPNP (beta-gamma-imidoadenosine 5-phosphate)is reported.
      Title: Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diphosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, phosphate group as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyphosphate:AMP phosphotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorus metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polyphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in polyphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of polyphosphate kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of polyphosphate kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    polyphosphate kinase
    NP_416996.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2623044..2625110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416996.1 polyphosphate kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416996.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3J2Q0, A0A1X3JFL3, A0A5E8GGG3, F4THH2, F4V4L7, F4VEV9
      Conserved Domains (1) summary
      COG0855
      Location:2 → 688
      Ppk; Polyphosphate kinase [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.