CDC42 Rho family GTPase CDC42 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CDC42
Gene description: Rho family GTPase CDC42
Primary source: SGD:S000004219
Locus tag: YLR229C
See related: AllianceGenome:SGD:S000004219
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GTPase activity. Involved in several processes, including budding cell apical bud growth; budding cell isotropic bud growth; and invasive growth in response to glucose limitation. Acts upstream of or within nuclear membrane organization. Located in several cellular components, including cellular bud tip; fungal-type vacuole membrane; and mating projection tip. Part of incipient cellular bud site. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to several human genes including CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (604212..604787, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chaperone-Dependent Degradation of Cdc42 Promotes Cell Polarity and Shields the Protein from Aggregation.
Title: Chaperone-Dependent Degradation of Cdc42 Promotes Cell Polarity and Shields the Protein from Aggregation.
Unexplored Cdc42 functions at the budding yeast nucleus suggested by subcellular localization.
Title: Unexplored Cdc42 functions at the budding yeast nucleus suggested by subcellular localization.
Regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway.
Title: Regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway.
Cdc42-Specific GTPase-Activating Protein Rga1 Squelches Crosstalk between the High-Osmolarity Glycerol (HOG) and Mating Pheromone Response MAPK Pathways.
Title: Cdc42-Specific GTPase-Activating Protein Rga1 Squelches Crosstalk between the High-Osmolarity Glycerol (HOG) and Mating Pheromone Response MAPK Pathways.
Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling.
Title: Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling.
Functions for Cdc42p BEM adaptors in regulating a differentiation-type MAP kinase pathway.
Title: Functions for Cdc42p BEM adaptors in regulating a differentiation-type MAP kinase pathway.
Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases.
Title: Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases.
Yeast daughter cells can polarize Cdc42 before CDK activation at start. This polarization operates via a positive feedback loop mediated by the Cdc42 effector Ste20.
Title: Cell-cycle control of cell polarity in yeast.
In yeast cells, Cdc42 polarization involves a positive feedback loop in which effectors called p21-activated kinases (PAKs) act to recruit a Cdc42-directed guanine nucleotide exchange factor (GEF), generating more GTP-Cdc42 in areas that already have GTP-Cdc42. The GTPase-interacting components (GICs) Gic1 and Gic2 are also Cdc42 effectors, and have been implicated in regulation of the actin and septin cytoskeleton.
Title: A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.
Using optogenetics, the authors probe yeast polarization and find that local recruitment of Cdc24 or Bem1 is sufficient to induce polarization by triggering self-sustaining Cdc42 activity.
Title: Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in budding cell apical bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in budding cell isotropic bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nuclear membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of exocyst localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in septin ring organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in organelle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in septin ring	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rho family GTPase CDC42

NP_013330.1

EC 3.6.5.2

Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; acts with ESCRT proteins at sites of nuclear envelope and ER fission; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

604212..604787 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182116.1 → NP_013330.1 TPA: Rho family GTPase CDC42 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013330.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYN1, P19073, Q05978

UniProtKB/TrEMBL

B3RHB7, B5VNE6, C7GT25, C8ZDJ3, N1NZF8

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family