Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppargc1aprovided by MGI
Official Full Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alphaprovided by MGI
Primary source: MGI:MGI:1342774
See related: Ensembl:ENSMUSG00000029167 AllianceGenome:MGI:1342774
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha
Summary: This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Broad expression in heart adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C1; 5 27.02 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (51611591..52273316, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (51454249..52115853, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGC-1alpha in the hippocampus mediates depressive-like and stress-coping behaviours and regulates excitatory synapses in the dentate gyrus in mice.
Title: PGC-1α in the hippocampus mediates depressive-like and stress-coping behaviours and regulates excitatory synapses in the dentate gyrus in mice.
Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1alpha overexpression or ablation of IDO1 or CD38.
Title: Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1alpha.
Title: Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
Exercise enhances placental labyrinth trophoblast development by activation of PGC-1alpha and FNDC5/irisindagger.
Title: Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.
An enriched environment ameliorates maternal sleep deprivation-induced cognitive impairment in aged mice by improving mitochondrial function via the Sirt1/PGC-1alpha pathway.
Title: An enriched environment ameliorates maternal sleep deprivation-induced cognitive impairment in aged mice by improving mitochondrial function via the Sirt1/PGC-1α pathway.
Peroxisome proliferator-activated receptor gamma coactivator 1alpha regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation.
Title: Peroxisome proliferator-activated receptor γ coactivator 1α regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation.
Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1alpha.
Title: Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1α.
Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator-activated receptor gamma coactivator 1 alpha.
Title: Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator-activated receptor gamma coactivator 1 alpha.
PGC1alpha deficiency reverses cholestasis-induced liver injury via attenuating hepatic inflammation and promoting bile duct remodeling.
Title: PGC1α deficiency reverses cholestasis-induced liver injury via attenuating hepatic inflammation and promoting bile duct remodeling.
PGC-1alpha affects cochlear pericytes migration in noise-exposed mice.
Title: PGC-1α affects cochlear pericytes migration in noise-exposed mice.

Submit: New GeneRIF Correction See all GeneRIFs (618)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_49176-49177:1118326844:1 (e-PCR)
- UniSTS:477493

Ppargc1a (e-PCR), detects polymorphism
- UniSTS:531399

PPARGC1A__5755 (e-PCR)
- UniSTS:463821

Ppargc1a (e-PCR), detects polymorphism
- UniSTS:479198

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of progesterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within respiratory electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in response to activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to muscle activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of euchromatin	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Names: PPAR-gamma coactivator 1-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402987.1 → NP_001389916.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b

Status: REVIEWED

Source sequence(s)

AC111037, AC116763
NM_001402988.1 → NP_001389917.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform c

Status: REVIEWED

Source sequence(s)

AC111037, AC116763, AC158149
NM_001402989.1 → NP_001389918.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform d

Status: REVIEWED

Source sequence(s)

AC116763
NM_001402990.1 → NP_001389919.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

Status: REVIEWED

Source sequence(s)

AC116763, AC163408
NM_001402991.1 → NP_001389920.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

Status: REVIEWED

Source sequence(s)

AC116763
NM_008904.3 → NP_032930.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a

See identical proteins and their annotated locations for NP_032930.1

Status: REVIEWED

Source sequence(s)

AC116763

Consensus CDS

CCDS19282.1

UniProtKB/Swiss-Prot

L0AM20, L0AN96, L0APB0, O70343, Q3UP72

UniProtKB/TrEMBL

A0A0G2JGG3

Related

ENSMUSP00000117040.2, ENSMUST00000132734.8

Conserved Domains (1) summary

cd12623
Location:674 → 764

RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins

RNA

NR_027710.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763
NR_132764.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763, BB853729, JX866948
NR_175325.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC111037, AC116763, AC158149
NR_175326.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763
NR_175327.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

51611591..52273316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503775.2 → XP_006503838.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2

UniProtKB/TrEMBL

A0A0G2JGG3

Conserved Domains (1) summary

cd12623
Location:670 → 760

RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
XM_036164894.1 → XP_036020787.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

Conserved Domains (1) summary

cd12623
Location:674 → 764

RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
XM_017320718.3 → XP_017176207.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

Conserved Domains (1) summary

cd12623
Location:549 → 639

RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
XM_030254205.2 → XP_030110065.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

Conserved Domains (1) summary

cd12623
Location:549 → 639

RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins