Brd4 bromodomain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brd4provided by MGI
Official Full Name: bromodomain containing 4provided by MGI
Primary source: MGI:MGI:1888520
See related: Ensembl:ENSMUSG00000024002 AllianceGenome:MGI:1888520
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brd5; MCAP; HUNK1; WI-11513
Summary: Enables several functions, including RNA polymerase II C-terminal domain binding activity; chromatin binding activity; and protein serine/threonine kinase activity. Acts upstream of or within several processes, including histone acetylation; inner cell mass cell proliferation; and protein autophosphorylation. Located in chromatin and condensed nuclear chromosome. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 17.8), spleen adult (RPKM 13.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.39 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (32415246..32503717, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32196272..32284743, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.
Title: TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.
Apoptotic body-inspired nanotherapeutics efficiently attenuate osteoarthritis by targeting BRD4-regulated synovial macrophage polarization.
Title: Apoptotic body-inspired nanotherapeutics efficiently attenuate osteoarthritis by targeting BRD4-regulated synovial macrophage polarization.
BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation.
Title: BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation.
BRD4 Regulates Glycolysis-Dependent Nos2 Expression in Macrophages Upon H pylori Infection.
Title: BRD4 Regulates Glycolysis-Dependent Nos2 Expression in Macrophages Upon H pylori Infection.
The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma.
Title: The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma.
EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes.
Title: EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes.
Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping.
Title: Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping.
BRD4 Inhibition Enhances the Antitumor Effects of Radiation Therapy in a Murine Breast Cancer Model.
Title: BRD4 Inhibition Enhances the Antitumor Effects of Radiation Therapy in a Murine Breast Cancer Model.
Bromodomain protein 4 mediates the roles of TGFbeta1-induced Stat3 signaling in mouse liver fibrogenesis.
Title: Bromodomain protein 4 mediates the roles of TGFβ1-induced Stat3 signaling in mouse liver fibrogenesis.
Bromodomain protein 4 is a key molecular driver of TGFbeta1-induced hepatic stellate cell activation.
Title: Bromodomain protein 4 is a key molecular driver of TGFβ1-induced hepatic stellate cell activation.

Submit: New GeneRIF Correction See all GeneRIFs (124)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (5) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237620

WI-11513 (e-PCR), detects polymorphism
- UniSTS:144767

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables P-TEFb complex binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II C-terminal domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II C-terminal domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner cell mass cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain-containing protein 4

Names: bromodomain-containing 5; fsh-like protein; mitotic chromosome-associated protein

NP_001273559.1

EC 3.1.1.31

NP_065254.3

EC 3.1.1.31

NP_932762.2

EC 3.1.1.31

XP_006524746.1

EC 3.1.1.31

XP_006524747.1

EC 3.1.1.31

XP_006524748.1

EC 3.1.1.31

XP_006524749.1

EC 3.1.1.31

XP_006524751.1

EC 3.1.1.31

XP_006524752.1

EC 3.1.1.31

XP_006524754.1

EC 3.1.1.31

XP_006524756.1

EC 3.1.1.31

XP_017173077.1

EC 3.1.1.31

XP_030105784.1

EC 3.1.1.31

XP_030105785.1

EC 3.1.1.31

XP_030105786.1

EC 3.1.1.31

XP_030105787.1

EC 3.1.1.31

XP_030105790.1

EC 3.1.1.31

XP_030105791.1

EC 3.1.1.31

XP_030105792.1

EC 3.1.1.31

XP_036016585.1

EC 3.1.1.31

XP_036016586.1

EC 3.1.1.31

XP_036016587.1

EC 3.1.1.31

XP_036016588.1

EC 3.1.1.31

XP_036016589.1

EC 3.1.1.31

XP_036016590.1

EC 3.1.1.31

XP_036016591.1

EC 3.1.1.31

XP_036016592.1

EC 3.1.1.31

XP_036016593.1

EC 3.1.1.31

XP_036016594.1

EC 3.1.1.31

XP_036016595.1

EC 3.1.1.31

XP_036016596.1

EC 3.1.1.31

XP_036016597.1

EC 3.1.1.31

XP_036016598.1

EC 3.1.1.31

XP_036016599.1

EC 3.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286630.1 → NP_001273559.1 bromodomain-containing protein 4 isoform 3

See identical proteins and their annotated locations for NP_001273559.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AK147545, BY779550, CJ192204

Consensus CDS

CCDS70784.1

UniProtKB/TrEMBL

Q3UH70

Related

ENSMUSP00000003726.9, ENSMUST00000003726.16

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
NM_020508.4 → NP_065254.3 bromodomain-containing protein 4 isoform 1

See identical proteins and their annotated locations for NP_065254.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) has two alternate splice sites, one in the 5' UTR and one in the 5' coding region, compared to variant 3. The resulting isoform (1) lacks an internal aa, compared to isoform 3.

Source sequence(s)

AK147545, BY779550, CJ192204

Consensus CDS

CCDS50057.1

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Related

ENSMUSP00000113070.2, ENSMUST00000121285.8

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
NM_198094.2 → NP_932762.2 bromodomain-containing protein 4 isoform 2

See identical proteins and their annotated locations for NP_932762.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has two alternate splice sites, one in the 5' UTR and one in the 5' coding region, and also lacks several exons but includes an alternate 3' terminal exon, compared to variant 3. The resulting isoform (2) lacks an internal aa, and has a shorter and distinct C-terminus, compared to isoform 3.

Source sequence(s)

AF461396, BC138834, BY779550

Consensus CDS

CCDS37554.1

UniProtKB/TrEMBL

B2RSE4

Related

ENSMUSP00000112474.3, ENSMUST00000120276.9

Conserved Domains (3) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

32415246..32503717 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524691.2 → XP_006524754.1 bromodomain-containing protein 4 isoform X4

Conserved Domains (5) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:799 → 1212

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1325 → 1367

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006524688.3 → XP_006524751.1 bromodomain-containing protein 4 isoform X2

See identical proteins and their annotated locations for XP_006524751.1

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006524689.4 → XP_006524752.1 bromodomain-containing protein 4 isoform X2

See identical proteins and their annotated locations for XP_006524752.1

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006524683.4 → XP_006524746.1 bromodomain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006524746.1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_030249930.2 → XP_030105790.1 bromodomain-containing protein 4 isoform X6

Conserved Domains (4) summary

cd05498
Location:206 → 307

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:644 → 1082

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:462 → 526

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1210 → 1252

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160698.1 → XP_036016591.1 bromodomain-containing protein 4 isoform X2

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006524684.4 → XP_006524747.1 bromodomain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006524747.1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_030249931.2 → XP_030105791.1 bromodomain-containing protein 4 isoform X6

Conserved Domains (4) summary

cd05498
Location:206 → 307

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:644 → 1082

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:462 → 526

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1210 → 1252

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160701.1 → XP_036016594.1 bromodomain-containing protein 4 isoform X5

Conserved Domains (4) summary

cd05498
Location:207 → 308

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:645 → 1083

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:463 → 527

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1211 → 1253

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_030249932.2 → XP_030105792.1 bromodomain-containing protein 4 isoform X6

Conserved Domains (4) summary

cd05498
Location:206 → 307

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:644 → 1082

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:462 → 526

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1210 → 1252

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160703.1 → XP_036016596.1 bromodomain-containing protein 4 isoform X6

Conserved Domains (4) summary

cd05498
Location:206 → 307

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:644 → 1082

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:462 → 526

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1210 → 1252

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006524693.4 → XP_006524756.1 bromodomain-containing protein 4 isoform X6

Conserved Domains (4) summary

cd05498
Location:206 → 307

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:644 → 1082

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:462 → 526

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1210 → 1252

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160700.1 → XP_036016593.1 bromodomain-containing protein 4 isoform X5

Conserved Domains (4) summary

cd05498
Location:207 → 308

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:645 → 1083

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:463 → 527

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1211 → 1253

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_030249926.2 → XP_030105786.1 bromodomain-containing protein 4 isoform X2

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_030249925.2 → XP_030105785.1 bromodomain-containing protein 4 isoform X2

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_030249927.2 → XP_030105787.1 bromodomain-containing protein 4 isoform X2

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006524686.3 → XP_006524749.1 bromodomain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006524749.1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006524685.3 → XP_006524748.1 bromodomain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006524748.1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160697.1 → XP_036016590.1 bromodomain-containing protein 4 isoform X2

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160693.1 → XP_036016586.1 bromodomain-containing protein 4 isoform X1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160696.1 → XP_036016589.1 bromodomain-containing protein 4 isoform X2

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160692.1 → XP_036016585.1 bromodomain-containing protein 4 isoform X1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160694.1 → XP_036016587.1 bromodomain-containing protein 4 isoform X1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_030249924.2 → XP_030105784.1 bromodomain-containing protein 4 isoform X2

UniProtKB/Swiss-Prot

B0V2V7, Q8VHF7, Q8VHF8, Q9ESU6

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:792 → 1230

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1266 → 1307

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1358 → 1400

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160699.1 → XP_036016592.1 bromodomain-containing protein 4 isoform X3

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:800 → 1213

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1234 → 1275

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1326 → 1368

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_017317588.3 → XP_017173077.1 bromodomain-containing protein 4 isoform X5

Conserved Domains (4) summary

cd05498
Location:207 → 308

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:645 → 1083

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:463 → 527

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1211 → 1253

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160695.1 → XP_036016588.1 bromodomain-containing protein 4 isoform X1

UniProtKB/TrEMBL

Q3UH70

Conserved Domains (6) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:793 → 1231

PHA03247; large tegument protein UL36; Provisional

pfam13868
Location:1267 → 1308

TPH; Trichohyalin-plectin-homology domain

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1359 → 1401

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160702.1 → XP_036016595.1 bromodomain-containing protein 4 isoform X5

Conserved Domains (4) summary

cd05498
Location:207 → 308

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:645 → 1083

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:463 → 527

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1211 → 1253

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160704.1 → XP_036016597.1 bromodomain-containing protein 4 isoform X5

Conserved Domains (4) summary

cd05498
Location:207 → 308

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:645 → 1083

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:463 → 527

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1211 → 1253

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_036160706.1 → XP_036016599.1 bromodomain-containing protein 4 isoform X8

UniProtKB/TrEMBL

B2RSE4

Conserved Domains (3) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation
XM_036160705.1 → XP_036016598.1 bromodomain-containing protein 4 isoform X7

Conserved Domains (3) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:355 → 456

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:611 → 675

BET; Bromodomain extra-terminal - transcription regulation