U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    UBE2D3 ubiquitin conjugating enzyme E2 D3 [ Homo sapiens (human) ]

    Gene ID: 7323, updated on 7-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    UBE2D3provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 D3provided by HGNC
    Primary source
    HGNC:HGNC:12476
    See related
    Ensembl:ENSG00000109332 MIM:602963; AllianceGenome:HGNC:12476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC4/5; UBCH5C; E2(17)KB3
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    4q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (102794383..102868895, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (106108341..106183222, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (103715540..103790052, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene mannosidase beta Neighboring gene WD repeat domain 12 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr4:103675856-103676033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15599 Neighboring gene uncharacterized LOC102723704 Neighboring gene uncharacterized LOC124900743 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:103746355-103747554 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:103748137-103748698 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:103748699-103749260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21761 Neighboring gene UBE2D3 antisense RNA 1 Neighboring gene RNA, U7 small nuclear 151 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15603 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene solute carrier family 9 member B1 Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 7

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control. Yalçin Z, et al. Mol Cell Proteomics, 2023 Jun. PMID 37059365, Free PMC Article
    2. UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo. Gao X, et al. Oncotarget, 2016 May 31. PMID 27105523, Free PMC Article
    3. Replication of two novel susceptibility loci for non-syndromic orofacial clefts in a Chinese population. Pan Y, et al. Oral Dis, 2011 Apr. PMID 20860768
    4. Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase. Levin I, et al. Proc Natl Acad Sci U S A, 2010 Feb 16. PMID 20133640, Free PMC Article
    5. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Hattori H, et al. Blood, 2007 Jul 15. PMID 17420285, Free PMC Article

    See all (491) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.
      Title: Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.
    2. UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.
      Title: UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.
    3. Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3.
      Title: Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3.
    4. UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP.
      Title: UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP.
    5. Together with Riplet, Ube2D3 promotes covalent conjugation of polyubiquitin chains to RIG-I, while Ube2N preferentially facilitates production of unanchored chains. In the presence of these chains, RIG-I induces MAVS aggregation directly on the mitochondria. Data thus reveal two essential mechanisms underlying the activation of RIG-I and MAVS for triggering innate immune signaling in response to viral infection in cells.
      Title: Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.
    6. Findings indicate that UBE2D3 enhances radiosensitivity of EC109 cells by degradating hTERT through the ubiquitin proteolysis pathway.
      Title: UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
    7. Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual.
      Title: Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.
    8. This study demonistrated by Gene expression profile that UBE3D3 upregulaion in fibroblasts of Huntington's disease patients.
      Title: Gene expression profile in fibroblasts of Huntington's disease patients and controls.
    9. These data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with UbcH5 and the function to suppress it.
      Title: Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.
    10. UbcH5c~Ubiqitin binding stabilizes an active conformation of the Shigella flexneri OspG kinase, greatly enhancing its activity.
      Title: E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC5416, MGC43926

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K6-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin-conjugating enzyme E2 D3
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme D3
    E2 ubiquitin-conjugating enzyme D3
    ubiquitin carrier protein D3
    ubiquitin conjugating enzyme E2D 3
    ubiquitin-conjugating enzyme E2(17)KB 3
    ubiquitin-conjugating enzyme E2-17 kDa 3
    ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
    ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)
    ubiquitin-protein ligase D3
    NP_001287724.1
    NP_003331.1
    NP_871615.1
    NP_871616.1
    NP_871617.1
    NP_871618.1
    NP_871619.1
    NP_871620.1
    NP_871621.1
    NP_871622.1
    XP_024309970.1
    XP_054206763.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300795.2 → NP_001287724.1  ubiquitin-conjugating enzyme E2 D3 isoform 4

      See identical proteins and their annotated locations for NP_001287724.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC018797, AI651378, AK127304, BQ719030, BU677139, CD242548, DA550074, DB234695
      Consensus CDS
      CCDS75172.1
      UniProtKB/TrEMBL
      D6RAH7, D6RFM0
      Related
      ENSP00000424359.1, ENST00000507845.5
      Conserved Domains (1) summary
      cl00154
      Location:1 → 117
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_003340.6 → NP_003331.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_003331.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AC018797, BC003395, BM750658, BM967209, DA557036
      Consensus CDS
      CCDS3660.1
      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000378280.4, ENST00000394801.8
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_181886.3 → NP_871615.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_871615.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' UTR, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC018797, BC003395, BM750658, BM788287, BM967209
      Consensus CDS
      CCDS3660.1
      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000378283.2, ENST00000394804.6
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_181887.3 → NP_871616.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_871616.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC018797, BM967209, DA588940, U39318
      Consensus CDS
      CCDS3660.1
      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000318494.7, ENST00000321805.11
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. NM_181888.3 → NP_871617.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_871617.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a segment in the 5' UTR, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC018797, BC003395, BM750658, BM967209, DA335600
      Consensus CDS
      CCDS3660.1
      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000344069.8, ENST00000349311.12
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    6. NM_181889.2 → NP_871618.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_871618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' UTR exon, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC018797, AK315775, BC003395, BM967209, HY035067
      Consensus CDS
      CCDS3660.1
      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000378282.5, ENST00000394803.9
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    7. NM_181890.3 → NP_871619.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_871619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate 5' UTR exon, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC018797, BC003395, BM967209, HY109217
      Consensus CDS
      CCDS3660.1
      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000337208.3, ENST00000338145.7
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    8. NM_181891.3 → NP_871620.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_871620.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an additional segment in the 5' UTR, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC018797, BC003395, BM967209, DA494746
      Consensus CDS
      CCDS3660.1
      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000396901.2, ENST00000453744.7
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    9. NM_181892.4 → NP_871621.1  ubiquitin-conjugating enzyme E2 D3 isoform 2

      See identical proteins and their annotated locations for NP_871621.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and has an additional exon in the 3' region, as compared to variant 1. It encodes isoform 2, which has a distinct and one aa longer C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC018797, AK095822, BM967209
      Consensus CDS
      CCDS3661.1
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000345285.5, ENST00000343106.9
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    10. NM_181893.3 → NP_871622.1  ubiquitin-conjugating enzyme E2 D3 isoform 3

      See identical proteins and their annotated locations for NP_871622.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two consecutive 5' exons, but has an alternate 5' exon, which contains an upstream in-frame start codon, as compared to variant 1. It encodes isoform 3, which has a distinct and two aa longer N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC018797, BM967209, DA965437, HY109217
      Consensus CDS
      CCDS3659.1
      UniProtKB/TrEMBL
      A0A087WY85
      Related
      ENSP00000349722.6, ENST00000357194.10
      Conserved Domains (1) summary
      cl00154
      Location:6 → 148
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      102794383..102868895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454202.2 → XP_024309970.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
      UniProtKB/TrEMBL
      A0A087WY85
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      106108341..106183222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350788.1 → XP_054206763.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

      UniProtKB/Swiss-Prot
      A6NJ93, A6NJB1, A6NM99, P47986, P61077, Q6IB88, Q6NXS4, Q8N924
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61077.1 GenPept UniProtKB/Swiss-Prot:P61077

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous