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    PURG purine rich element binding protein G [ Homo sapiens (human) ]

    Gene ID: 29942, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PURGprovided by HGNC
    Official Full Name
    purine rich element binding protein Gprovided by HGNC
    Primary source
    HGNC:HGNC:17930
    See related
    Ensembl:ENSG00000172733 MIM:618041; AllianceGenome:HGNC:17930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PURGA; PURGB; PURG-A; PURG-B
    Summary
    The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
    Expression
    Biased expression in brain (RPKM 1.4), testis (RPKM 1.1) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30995802..31033356, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (31276938..31314481, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30853318..30890872, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene uncharacterized LOC105379357 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:30763109-30763340 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136 Neighboring gene NANOG hESC enhancer GRCh37_chr8:30776396-30776897 Neighboring gene lysophosphatidylglycerol acyltransferase 1 pseudogene 1 Neighboring gene MPRA-validated peak6979 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:30891079-30891600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30914375-30914876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30914877-30915376 Neighboring gene WRN RecQ like helicase Neighboring gene SUMO2 pseudogene 16 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:31029565-31030764 Neighboring gene uncharacterized LOC105379358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. Liu H, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034829, Free PMC Article
    2. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. Xie L, et al. PLoS Genet, 2012. PMID 23284306, Free PMC Article
    3. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Kim DY, et al. Mol Cell, 2013 Feb 21. PMID 23333304, Free PMC Article
    4. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation
      Title: Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif modulates the expression of purine-rich element binding protein G (PURG) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119274

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding HDA PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-rich negative regulatory element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    purine-rich element-binding protein gamma
    Names
    Pur-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015508.3 → NP_001015508.1  purine-rich element-binding protein gamma isoform B

      See identical proteins and their annotated locations for NP_001015508.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
      Source sequence(s)
      AC008066, AW170055, AY077841
      Consensus CDS
      CCDS34878.1
      UniProtKB/Swiss-Prot
      Q9UJV8
      Related
      ENSP00000345168.2, ENST00000339382.3
      Conserved Domains (1) summary
      pfam04845
      Location:57 → 290
      PurA; PurA ssDNA and RNA-binding protein

    2. NM_001323311.2 → NP_001310240.1  purine-rich element-binding protein gamma isoform A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) differs in the 5' UTR compared to variant A. Variants A and C encode the same isoform (A).
      Source sequence(s)
      AC084736, AF195513, DR003356
      Consensus CDS
      CCDS6081.1
      UniProtKB/Swiss-Prot
      Q8TE64, Q9UJV8
      Related
      ENSP00000466881.2, ENST00000523392.2
      Conserved Domains (1) summary
      pfam04845
      Location:57 → 321
      PurA; PurA ssDNA and RNA-binding protein

    3. NM_001323312.2 → NP_001310241.1  purine-rich element-binding protein gamma isoform B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) differs in the 5' and 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
      Source sequence(s)
      AC008066, AC084736, AW170055, AY077841, DR003356
      Consensus CDS
      CCDS34878.1
      UniProtKB/Swiss-Prot
      Q9UJV8
      Conserved Domains (1) summary
      pfam04845
      Location:57 → 290
      PurA; PurA ssDNA and RNA-binding protein

    4. NM_013357.2 → NP_037489.1  purine-rich element-binding protein gamma isoform A

      See identical proteins and their annotated locations for NP_037489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A). Variants A and C encode the same isoform (A).
      Source sequence(s)
      AF195513
      Consensus CDS
      CCDS6081.1
      UniProtKB/Swiss-Prot
      Q8TE64, Q9UJV8
      Related
      ENSP00000418721.1, ENST00000475541.2
      Conserved Domains (1) summary
      pfam04845
      Location:57 → 321
      PurA; PurA ssDNA and RNA-binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      30995802..31033356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      31276938..31314481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJV8.1 GenPept UniProtKB/Swiss-Prot:Q9UJV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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