Irf8 interferon regulatory factor 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irf8provided by MGI
Official Full Name: interferon regulatory factor 8provided by MGI
Primary source: MGI:MGI:96395
See related: Ensembl:ENSMUSG00000041515 AllianceGenome:MGI:96395
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myls; ICSBP; IRF-8; Icsbp1
Summary: The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression: Biased expression in spleen adult (RPKM 59.4), large intestine adult (RPKM 27.2) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 70.05 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (121463097..121483433)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (120736358..120756694)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Murine IRF8 Mutation Offers New Insight into Osteoclast and Root Resorption.
Title: Murine IRF8 Mutation Offers New Insight into Osteoclast and Root Resorption.
Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation.
Title: Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation.
A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation.
Title: A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation.
Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia.
Title: Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia.
Deacetylation of IRF8 inhibits iNOS expression and inflammation via SIRT1 in macrophages.
Title: Deacetylation of IRF8 inhibits iNOS expression and inflammation via SIRT1 in macrophages.
Hepatic interferon regulatory factor 8 expression suppresses hepatocellular carcinoma progression and enhances the response to anti-programmed cell death protein-1 therapy.
Title: Hepatic interferon regulatory factor 8 expression suppresses hepatocellular carcinoma progression and enhances the response to anti-programmed cell death protein-1 therapy.
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
Title: Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment.
Title: Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment.
Elevated TNF-alpha Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8.
Title: Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8.
Impact of the transcription factor IRF8 on limbal epithelial progenitor cells in a mouse model.
Title: Impact of the transcription factor IRF8 on limbal epithelial progenitor cells in a mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (180)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (7) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Icsbp (e-PCR), detects polymorphism
- UniSTS:143447

AI893568 (e-PCR)
- UniSTS:179835

Irf8 (e-PCR), detects polymorphism
- UniSTS:536528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicular B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germinal center B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune system process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasmacytoid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon regulatory factor 8

Names: interferon consensus sequence binding protein 1; interferon consensus sequence-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301811.1 → NP_001288740.1 interferon regulatory factor 8

See identical proteins and their annotated locations for NP_001288740.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK018533, AK137450, BF662476

Consensus CDS

CCDS22721.1

UniProtKB/Swiss-Prot

P23611

UniProtKB/TrEMBL

Q3U075, Q3U0X4, Q3U6F0, Q3UCV9, Q544J7

Related

ENSMUSP00000125029.2, ENSMUST00000162001.8

Conserved Domains (2) summary

pfam00605
Location:9 → 113

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:203 → 379

IRF-3; Interferon-regulatory factor 3
NM_008320.4 → NP_032346.1 interferon regulatory factor 8

See identical proteins and their annotated locations for NP_032346.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK018533, AK150370, AK151324, BF662476

Consensus CDS

CCDS22721.1

UniProtKB/Swiss-Prot

P23611

UniProtKB/TrEMBL

Q3U075, Q3U0X4, Q3U6F0, Q3UCV9, Q544J7

Related

ENSMUSP00000040245.4, ENSMUST00000047737.10

Conserved Domains (2) summary

pfam00605
Location:9 → 113

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:203 → 379

IRF-3; Interferon-regulatory factor 3