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    Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric [ Mus musculus (house mouse) ]

    Gene ID: 17833, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Muc5acprovided by MGI
    Official Full Name
    mucin 5, subtypes A and C, tracheobronchial/gastricprovided by MGI
    Primary source
    MGI:MGI:104697
    See related
    Ensembl:ENSMUSG00000037974 AllianceGenome:MGI:104697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MGM; 2210005L13Rik
    Summary
    Acts upstream of or within maintenance of lens transparency. Located in extracellular space. Is expressed in nasal cavity epithelium; respiratory system; stomach; and testis. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward stomach adult (RPKM 445.3) See more
    Orthologs
    human all
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    Genomic context

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    See Muc5ac in Genome Data Viewer
    Location:
    7 F5; 7 87.23 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141342695..141372964)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141788958..141819227)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene mucin 6, gastric Neighboring gene mucin 2 Neighboring gene STARR-seq mESC enhancer starr_20496 Neighboring gene mucin 5, subtype B, tracheobronchial Neighboring gene toll interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. Singanayagam A, et al. J Clin Invest, 2022 Apr 15. PMID 35239513, Free PMC Article
    2. Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice. Cho HY, et al. Toxicol Pathol, 2021 Jul. PMID 33938323, Free PMC Article
    3. Disulfide disruption reverses mucus dysfunction in allergic airway disease. Morgan LE, et al. Nat Commun, 2021 Jan 11. PMID 33431872, Free PMC Article
    4. Muc5ac null mice are predisposed to spontaneous gastric antro-pyloric hyperplasia and adenomas coupled with attenuated H. pylori-induced corpus mucous metaplasia. Muthupalani S, et al. Lab Invest, 2019 Dec. PMID 31399638, Free PMC Article
    5. Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway. Ge LT, et al. Int Immunopharmacol, 2016 Apr. PMID 26881857

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
      Title: House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
    2. [Dickkopf-1 inhibits the secretion of MUC5AC induced by Mycoplasma pneumoniae P1-C in mouse lung epithelial cells].
      Title: [Dickkopf-1 inhibits the secretion of MUC5AC induced by Mycoplasma pneumoniae P1-C in mouse lung epithelial cells].
    3. De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
      Title: De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
    4. Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
      Title: Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
    5. Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity.
      Title: Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity.
    6. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
      Title: Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
    7. Mucin 5AC Serves as the Nexus for beta-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.
      Title: Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.
    8. Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells.
      Title: Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells.
    9. Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
      Title: Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
    10. Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice.
      Title: Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of lens transparency IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mucus layer ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mucin-5AC
    Names
    gastric mucin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010844.3 → NP_034974.2  mucin-5AC precursor

      Status: VALIDATED

      Source sequence(s)
      AC175658, AC175742
      UniProtKB/TrEMBL
      E9QAQ8
      Conserved Domains (8) summary
      PHA02682
      Location:3007 → 3157
      PHA02682; ORF080 virion core protein; Provisional
      smart00041
      Location:3339 → 3411
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00216
      Location:890 → 1049
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:622 → 692
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:2052 → 2254
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01826
      Location:337 → 393
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:265 → 333
      C8; C8 domain
      pfam13330
      Location:1605 → 1691
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141342695..141372964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508499.2 → XP_006508562.1  mucin-5AC isoform X1

      UniProtKB/TrEMBL
      E9QAQ8
      Related
      ENSMUSP00000122353.4, ENSMUST00000155534.9
      Conserved Domains (8) summary
      PHA02682
      Location:3012 → 3162
      PHA02682; ORF080 virion core protein; Provisional
      smart00041
      Location:3344 → 3416
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00216
      Location:895 → 1054
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:627 → 697
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:2057 → 2259
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01826
      Location:341 → 397
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:269 → 337
      C8; C8 domain
      pfam13330
      Location:1610 → 1696
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region

    2. XM_006508500.2 → XP_006508563.1  mucin-5AC isoform X2

      UniProtKB/TrEMBL
      E9QAQ8
      Related
      ENSMUSP00000039699.8, ENSMUST00000041924.14
      Conserved Domains (8) summary
      PHA02682
      Location:2980 → 3130
      PHA02682; ORF080 virion core protein; Provisional
      smart00041
      Location:3312 → 3384
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00216
      Location:895 → 1054
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:627 → 697
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:1869 → 2227
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01826
      Location:341 → 397
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:269 → 337
      C8; C8 domain
      pfam13330
      Location:1610 → 1696
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    Nucleotide Protein Strain
    Heading Accession and Version

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