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    Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 373545, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Prkag2provided by RGD
    Official Full Name
    protein kinase AMP-activated non-catalytic subunit gamma 2provided by RGD
    Primary source
    RGD:727782
    See related
    Ensembl:ENSRNOG00000009085 AllianceGenome:RGD:727782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables AMP binding activity and protein kinase binding activity. Contributes to AMP-activated protein kinase activity. Involved in regulation of catalytic activity. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 35.3), Brain (RPKM 28.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (10744695..10985939)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10010890..10252155)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (6559153..6799888)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 2C Neighboring gene calcineurin B homologous protein 1-like Neighboring gene hypothetical LOC100359776 Neighboring gene uncharacterized LOC102554253 Neighboring gene uncharacterized LOC102554193 Neighboring gene uncharacterized LOC120102471 Neighboring gene Ras homolog, mTORC1 binding Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy with conduction system disease and muscular glycogenosis. Laforêt P, et al. Neuromuscul Disord, 2006 Mar. PMID 16487706
    2. Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Burwinkel B, et al. Am J Hum Genet, 2005 Jun. PMID 15877279, Free PMC Article
    3. Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Reiter AK, et al. Am J Physiol Endocrinol Metab, 2005 May. PMID 15613684
    4. Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Sidhu JS, et al. Circulation, 2005 Jan 4. PMID 15611370, Free PMC Article
    5. Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy. Gollob MH, et al. Circulation, 2001 Dec 18. PMID 11748095

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorylase kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of catalytic activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5'-AMP-activated protein kinase subunit gamma-2
    Names
    AMP-activated protein kinase gamma2 subunit
    AMPK gamma 2
    adenosine monophosphate-activated protein kinase gamma 2-subunit
    protein kinase, AMP-activated, gamma 2 non-catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398879.1 → NP_001385808.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Related
      ENSRNOP00000076857.1, ENSRNOT00000094824.1
      Conserved Domains (2) summary
      cd04618
      Location:266 → 403
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:429 → 552
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    2. NM_184051.1 → NP_908940.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 2

      See identical proteins and their annotated locations for NP_908940.1

      Status: PROVISIONAL

      Source sequence(s)
      AY348865
      UniProtKB/TrEMBL
      A6KJH6, F1LM70, Q6V7V4
      Conserved Domains (3) summary
      COG0517
      Location:192 → 308
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:35 → 164
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:191 → 310
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      10744695..10985939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235951.4 → XP_006236013.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X5

      UniProtKB/TrEMBL
      A0A140UHX4, A0A8I5Y6F6
      Related
      ENSRNOP00000062361.4
      Conserved Domains (3) summary
      COG0517
      Location:433 → 549
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:276 → 405
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:432 → 551
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    2. XM_063286390.1 → XP_063142460.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X8

    3. XM_063286391.1 → XP_063142461.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X9

    4. XM_006235949.4 → XP_006236011.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6F6
      Conserved Domains (3) summary
      COG0517
      Location:433 → 549
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:276 → 405
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:432 → 551
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    5. XM_063286389.1 → XP_063142459.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X4

    6. XM_017592729.3 → XP_017448218.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y6F6

    7. XM_017592730.3 → XP_017448219.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y6F6

    8. XM_039107960.2 → XP_038963888.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y6F6
      Conserved Domains (2) summary
      cd04618
      Location:218 → 355
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:381 → 479
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    9. XM_017592731.3 → XP_017448220.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6F6

    10. XM_039107963.2 → XP_038963891.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X12

      UniProtKB/TrEMBL
      Q4QRB9
      Conserved Domains (2) summary
      cd04618
      Location:115 → 252
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:278 → 376
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    11. XM_017592732.3 → XP_017448221.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X10

    12. XM_063286392.1 → XP_063142462.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X11

    13. XM_006235955.5 → XP_006236017.2  5'-AMP-activated protein kinase subunit gamma-2 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZQR3, Q4QRB9
      Related
      ENSRNOP00000080463.1

    14. XM_063286393.1 → XP_063142463.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X14

    15. XM_063286396.1 → XP_063142466.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X17

    16. XM_063286398.1 → XP_063142468.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X21

      UniProtKB/TrEMBL
      F1LM70, Q6V7V4

    17. XM_063286394.1 → XP_063142464.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X15

    18. XM_063286395.1 → XP_063142465.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X16

    19. XM_063286397.1 → XP_063142467.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X20

    20. XM_063286399.1 → XP_063142469.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X22

    21. XM_063286400.1 → XP_063142470.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X23

    22. XM_039107964.2 → XP_038963892.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X18

      Conserved Domains (2) summary
      cd04618
      Location:25 → 162
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:188 → 286
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    23. XM_039107965.2 → XP_038963893.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X19

      Conserved Domains (2) summary
      cd04618
      Location:24 → 161
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:187 → 285
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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