mt-Co2 cytochrome c oxidase II, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Co2provided by RGD
Official Full Name: cytochrome c oxidase II, mitochondrialprovided by RGD
Primary source: RGD:621872
See related: AllianceGenome:RGD:621872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: COII; COX2
Summary: Predicted to enable copper ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Involved in several processes, including lactation; positive regulation of cellular biosynthetic process; and positive regulation of necrotic cell death. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Biomarker of colorectal carcinoma and type 2 diabetes mellitus. Orthologous to several human genes including MTCO2P12 (MT-CO2 pseudogene 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (7006..7689)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (7006..7689)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Title: Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Cholate Disrupts Regulatory Functions of Cytochrome c Oxidase.
Title: Cholate Disrupts Regulatory Functions of Cytochrome c Oxidase.
COX-2/PGE2 facilitates fracture healing by activating the Wnt/beta-catenin signaling pathway.
Title: COX-2/PGE2 facilitates fracture healing by activating the Wnt/β-catenin signaling pathway.
Bradykinin and interleukin-1beta synergistically increase the expression of cyclooxygenase-2 through the RNA-binding protein HuR in rat dorsal root ganglion cells.
Title: Bradykinin and interleukin-1β synergistically increase the expression of cyclooxygenase-2 through the RNA-binding protein HuR in rat dorsal root ganglion cells.
Superoxide anion production and cytochrome c reduction are the consequences of the stimulated NADH consumption by cytochrome b5 reductase upon complex formation with cytochrome c and suggest a major role of this enzyme as an anti-apoptotic protein during cell death.
Title: Cytochrome b(5) reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c.
tumor necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxia at least partly via potentiation of energy generation
Title: Tumor necrosis factor receptor-associated protein 1 improves hypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II.
Specifically, our results suggest that CL 18:2omega6 content may positively influence mitochondrial COX activity thereby making this lipid molecule a potential factor related to mitochondrial health and function in skeletal muscle.
Title: Cardiolipin linoleic acid content and mitochondrial cytochrome c oxidase activity are associated in rat skeletal muscle.
Neuroprotective effects of triptolide might partially be related to its inhibitory effect on expression of COX-2 and PGE2.
Title: Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells.
VEGF production in PDGF-stimulated Hepatic stellate cells is dependent on the overexpression of COX-2 protein via the
Title: Hepatic stellate cells produce vascular endothelial growth factor via phospho-p44/42 mitogen-activated protein kinase/cyclooxygenase-2 pathway.
Berry diets did not alter COX-2 levels, but blueberry diet significantly reduced MnSOD levels in rats with reflux-induced esophageal adenocarcinoma.
Title: Effect of freeze-dried berries on the development of reflux-induced esophageal adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Cox2; co2; COII

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
contributes_to cytochrome-c oxidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 2

Names: cytochrome c oxidase subunit II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001665.2 Reference assembly

Range

7006..7689

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_665632.1 cytochrome c oxidase subunit II (mitochondrion) [Rattus norvegicus]

See identical proteins and their annotated locations for YP_665632.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P00406, Q37738, Q80WI7

UniProtKB/TrEMBL

A0A097PE04, Q8SEZ5, S5RZM8

Related

ENSRNOP00000046414.3

Conserved Domains (1) summary

MTH00098
Location:1 → 227

COX2; cytochrome c oxidase subunit II; Validated