Htr4 5-hydroxytryptamine receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr4provided by RGD
Official Full Name: 5-hydroxytryptamine receptor 4provided by RGD
Primary source: RGD:2850
See related: Ensembl:ENSRNOG00000019134 AllianceGenome:RGD:2850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and gamma-aminobutyric acid signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 13.0), Kidney (RPKM 3.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (58036277..58221327)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (55765981..55949921)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (57637013..57820317)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT4 receptors and cAMP-dependent mechanisms.
Title: Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT(4) receptors and cAMP-dependent mechanisms.
Hypertension exhibits 5-HT4 receptor as a modulator of sympathetic neurotransmission in the rat mesenteric vasculature.
Title: Hypertension exhibits 5-HT(4) receptor as a modulator of sympathetic neurotransmission in the rat mesenteric vasculature.
findings suggested that unilateral lesions of the Substantia Nigra induced working memory impairment and up-regulation of 5-HT4 receptors in the Lateral Habenula. Activation and blockade of LHb 5-HT4 receptors improved working memory, that were related to the change of monoamines levels.
Title: Activation and blockade of serotonin(4) receptors in the lateral habenula improve working memory in unilateral 6-hydroxydopamine-lesioned Parkinson's rats.
Results indicate that visceral nociceptive transmission through the caudal medulla is negatively modulated by descending serotonin type 4 receptor dependent mechanisms.
Title: The 5-HT(4) receptor-mediated inhibition of visceral nociceptive neurons in the rat caudal ventrolateral medulla.
Results support a specific role for 5-HT4-receptors in fine-tuning of the dynamic capacity of hippocampal synapses to express synaptic plasticity.
Title: The 5-hydroxytryptamine4 receptor enables differentiation of informational content and encoding in the hippocampus.
Study suggests a novel role for the 5-HT4 receptor in facilitation of dendrite formation in which intracellular signaling of PKA and the BDNF-TrkB system may be involved.
Title: Roles of the serotonin 5-HT4 receptor in dendrite formation of the rat hippocampal neurons in vitro.
5-HT4 receptor regulating insulin secretion and acting as a potential drug target in diabetes treatment
Title: Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion.
Data suggest a strong interaction between 5-HT4 and CB1 receptors within the nucleus accumbens shell
Title: Effect of nucleus accumbens shell 5-HT4 receptors on the impairment of ACPA-induced emotional memory consolidation in male Wistar rats.
Increased p11 expression by BDNF and imipramine unraveled a 5-HT4R-mediated modulation of cardiac Ca(2+) handling
Title: p11 modulates calcium handling through 5-HT₄R pathway in rat ventricular cardiomyocytes.
A novel apical 5-HT4 -mediated bicarbonate secretory pathway and an nitric oxide-dependent inhibitory mechanism are present in the proximal colon
Title: Luminal 5-HT stimulates colonic bicarbonate secretion in rats.

Submit: New GeneRIF Correction See all GeneRIFs (32)

General gene information

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Markers

Htr4 (e-PCR), detects polymorphism
- UniSTS:495967

RH138237 (e-PCR)
- UniSTS:220324

Htr4 (e-PCR), detects polymorphism
- UniSTS:532457

Htr4 (e-PCR), detects polymorphism
- UniSTS:532458

Htr4 (e-PCR), detects polymorphism
- UniSTS:532459

Htr4 (e-PCR), detects polymorphism
- UniSTS:532460

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables serotonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in cognition	TAS Traceable Author Statement more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in large intestinal transit	IEA Inferred from Electronic Annotation more info
involved_in large intestinal transit	ISO Inferred from Sequence Orthology more info
involved_in maintenance of gastrointestinal epithelium	IEA Inferred from Electronic Annotation more info
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
involved_in mucus secretion	IEA Inferred from Electronic Annotation more info
involved_in mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 4

Names: 5 hydroxytryptamine ( serotonin) receptor 4; 5-HT-4; 5-HT4 receptor (two splicing variants L and S); 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled; serotonin receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012853.2 → NP_036985.2 5-hydroxytryptamine receptor 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A6IXJ9, C4WYH2, F1LS47

Related

ENSRNOP00000025892.5, ENSRNOT00000025892.6

Conserved Domains (1) summary

cd15056
Location:20 → 323

7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

58036277..58221327

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254793.5 → XP_006254855.1 5-hydroxytryptamine receptor 4 isoform X2

See identical proteins and their annotated locations for XP_006254855.1

UniProtKB/TrEMBL

A0A140UHX7, A0A9K3Y826, A6IXJ7, C4WYH1, F1LM98

Related

ENSRNOP00000025871.6

Conserved Domains (2) summary

pfam00001
Location:36 → 312

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam05296
Location:138 → 329

TAS2R; Taste receptor protein (TAS2R)
XM_017600859.3 → XP_017456348.1 5-hydroxytryptamine receptor 4 isoform X1

UniProtKB/TrEMBL

A6IXJ9, C4WYH2, F1LS47

Conserved Domains (1) summary

cd15056
Location:20 → 323

7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors