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    acs-2 AMP-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565680, updated on 3-Mar-2024

    Summary

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    Gene symbol
    acs-2
    Gene description
    AMP-binding domain-containing protein
    Primary source
    WormBase:WBGene00009221
    Locus tag
    CELE_F28F8.2
    See related
    AllianceGenome:WB:WBGene00009221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (15567394..15569897)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AcetylCholine Receptor Neighboring gene tRNA-His Neighboring gene ncRNA Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection. Dasgupta M, et al. Infect Immun, 2020 Jul 21. PMID 32482643, Free PMC Article
    2. Proanthocyanidin trimer gallate modulates lipid deposition and fatty acid desaturation in Caenorhabditis elegans. Nie Y, et al. FASEB J, 2017 Nov. PMID 28760744
    3. Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity. Zuryn S, et al. Mech Ageing Dev, 2010 Sep. PMID 20688098
    4. The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. Liang B, et al. PLoS One, 2010 Mar 25. PMID 20360843, Free PMC Article
    5. Quantum dots increased fat storage in intestine of Caenorhabditis elegans by influencing molecular basis for fatty acid metabolism. Wu Q, et al. Nanomedicine, 2016 Jul. PMID 26956412

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
      Title: NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables medium-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AMP-binding domain-containing protein
    NP_506869.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15567394..15569897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074468.6 → NP_506869.1  AMP-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18693
      Conserved Domains (2) summary
      cd05917
      Location:244 → 595
      FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
      PRK08315
      Location:46 → 609
      PRK08315; AMP-binding domain protein; Validated
    Nucleotide Protein
    Heading Accession and Version

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