TH1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TH1provided by FlyBase
Primary source: FLYBASE:FBgn0010416
Locus tag: Dmel_CG9984
See related: AllianceGenome:FB:FBgn0010416
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9984; Dmel\CG9984; NELF; Nelf-D; NELF-D; NelfD
Summary: Enables RNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and negative regulation of transcription elongation from RNA polymerase II promoter. Located in nucleus; polytene chromosome interband; and polytene chromosome puff. Part of NELF complex and transcription repressor complex. Is expressed in several structures, including anlage in statu nascendi; anterior endoderm; anterior endoderm anlage; extended germ band embryo; and pole plasm. Orthologous to human NELFCD (negative elongation factor complex member C/D). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16388820..16391438, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16282853..16285471, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of NELF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NELF complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of transcription elongation factor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed