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    Syt12 Synaptotagmin 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32290, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Syt12provided by FlyBase
    Official Full Name
    Synaptotagmin 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0261085
    Locus tag
    Dmel_CG10617
    See related
    AllianceGenome:FB:FBgn0261085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10617; Dmel\CG10617; dsyt12; Syt 12; syt-12; syt12; SYT12
    Summary
    Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Predicted to be involved in calcium-ion regulated exocytosis; cellular response to calcium ion; and regulation of secretion by cell. Predicted to be integral component of membrane. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in indirect flight muscle cell. Orthologous to human SYT12 (synaptotagmin 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    11F1-11F1; 1-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13359248..13368179)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13253281..13262212)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45708 Neighboring gene long non-coding RNA:CR45709 Neighboring gene doublesex-Mab related 11E Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity. Zhang YV, et al. eNeuro, 2017 Mar-Apr. PMID 28303263, Free PMC Article
    2. Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. Park D, et al. J Neurosci, 2014 Sep 24. PMID 25253864, Free PMC Article
    3. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
    4. Function of Drosophila Synaptotagmins in membrane trafficking at synapses. Quiñones-Frías MC, et al. Cell Mol Life Sci, 2021 May. PMID 33619613, Free PMC Article
    5. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin 12
    Names
    CG10617-PA
    CG10617-PB
    Syt12-PA
    Syt12-PB
    syt12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13359248..13368179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132650.2 → NP_572878.1  synaptotagmin 12, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQJ2, Q9VYE1
      Related
      FBpp0073598
      Conserved Domains (2) summary
      cd08406
      Location:612 → 753
      C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
      pfam00168
      Location:503 → 602
      C2; C2 domain

    2. NM_001272584.1 → NP_001259513.1  synaptotagmin 12, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259513.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQJ2, Q9VYE1
      Conserved Domains (2) summary
      cd08406
      Location:612 → 753
      C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
      pfam00168
      Location:503 → 602
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQJ2 Q8MQJ2
    Q9VYE1 Q9VYE1

    Gene LinkOut

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