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Series GSE8491 Query DataSets for GSE8491
Status Public on Sep 22, 2008
Title The Transcriptome of the rat hypothalamo-neurohypophyseal system is highly strain-dependant
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary We have used microarrays to comprehensively describe the transcriptomes of the supraoptic nucleus (SON), the paraventricular nucleus (PVN) and the neurointermediate lobe (NIL) of adult male Sprague-Dawley (SD) and Wistar-Kyoto (WKY) rats, as well as the paraventricular nucleus of Wistar (WIST) rats. Comparison of these gene lists has enabled us to identify surprisingly large differences in hypothalamo-neurohypophyseal system gene expression patterns in these three strains. We have also shown that different transcript populations are enriched in the PVN and the SON of SD and WKY rats. The transcriptome differences catalogued here may be molecular substrates for the neuro-humoral phenotypic differences exhibited by different strains of rats.
Keywords: Transcriptome, Hypothalamo-neurohypophyseal system, Genetic
 
Overall design For each experimental group (SON-WKY, PVN-WKY, NIL-WKY, SON-SD, PVN-SD, NIL-SD, PVN-WISTAR) five chips were hybridised with independantly pooled RNA from a biological n=5.
 
Contributor(s) Hindmarch C, Yao S, Hesketh S, Jessop D, Harbuz M, Paton J, Murphy D
Citation(s) 18001331
Submission date Jul 16, 2007
Last update date Jul 31, 2017
Contact name DAVID MURPHY
Organization name University of Bristol
Department Medicine and Dentistry
Lab Laboratories for Integrative Neuroscience and Endocrinolgy
Street address Whitson Street
City Bristol
State/province AVON
ZIP/Postal code BS1 3NY
Country United Kingdom
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (35)
GSM69461 CH2120
GSM69462 CH2121
GSM69463 CH2122
Relations
BioProject PRJNA101587

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Supplementary file Size Download File type/resource
GSE8491_RAW.tar 69.0 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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