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| Status |
Public on Apr 02, 2014 |
| Title |
The effect of genotype and in utero environment on inter-individual variation in neonate DNA methylomes (methylomes) |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
We surveyed the genotypes and DNA methylomes of 237 neonates and found 1423 punctate regions of the methylome that were highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop of homogeneity. Although methQTLs were readily detected in neonatal methylomes, genotype alone did not explain the majority of the VMRs.
We found that the best explanation for 75% of VMRs was the interaction of genotype with different in utero environments, including maternal smoking, maternal depression, maternal BMI, infant birth weight, gestational age and birth order.
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| Overall design |
We surveyed the genotypes and DNA methylomes of 237 neonates and included 32 technical replicates
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| Contributor(s) |
Holbrook JD |
| Citation(s) |
24709820 |
| Submission date |
Jan 03, 2014 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Dennis Wang |
| Organization name |
Singapore Institute for Clinical Sciences
|
| Street address |
30 Medical Drive
|
| City |
Singapore |
| ZIP/Postal code |
117609 |
| Country |
Singapore |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (237)
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| This SubSeries is part of SuperSeries: |
| GSE54446 |
The effect of genotype and in utero environment on inter-individual variation in neonate DNA methylomes |
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| Relations |
| BioProject |
PRJNA236558 |
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