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| Status |
Public on Feb 01, 2012 |
| Title |
Functional analysis of the cytoprotective transcription factor Nrf2 in skin morphogenesis and disease: Identification of Nrf2 target genes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The Nrf2 transcription factor is a key player in the cellular stress response, which regulates the expression of important antioxidant enzymes and other cytoprotective proteins. We recently generated a novel transgenic mouse model to determine the function of Nrf2 in the skin. These mice revealed interesting phenotypic abnormalities, including hyperkeratosis and acanthosis. To gain insight into the underlying molecular mechanisms, we wanted to identify genes, which are differentially expressed in the skin of wild-type and mutant mice before the onset of phenotypic abnormalities.
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| Overall design |
RNA from whole skin of 3 single P2.5 K5cre-caNrf2 (tg/tg) and 3 single P2.5 K5cre-wt (tg/wt=control) mice were used
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| Contributor(s) |
Schäfer M, Werner S, Zoller S, Aquino C, Rehrauer H |
| Citation(s) |
22383093 |
| Submission date |
Jan 17, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Matthias Schäfer |
| E-mail(s) |
matthias.schaefer@cell.biol.ethz.ch
|
| Phone |
+41-44-633 3406
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| Fax |
+41-44-633 1174
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| Organization name |
ETH Zürich
|
| Department |
Department of Cell Biology
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| Lab |
Werner
|
| Street address |
Schafmattstrasse 18
|
| City |
Zürich |
| State/province |
ZH |
| ZIP/Postal code |
8093 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA150787 |
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