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| Status |
Public on Oct 21, 2012 |
| Title |
Expression data in inguinal adipose tissue at different circadian times |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Peripheral circadian clocks regulate many aspects of physiology. In this study we deleted the core circadian clock component Bmal1 specifically in mouse adipocytes in order to study the role of the adipocyte clock in energy homeostasis and body weight. We used microarrays to indentify changes in gene expression in the adipose tissue of mice lacking a functional adipocyte circadian clock and identified a small number of up- and down- regulated genes.
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| Overall design |
Adipose tissues were isolated from inguinal adipose fat pads at four different times of the diurnal cycle under constant darkness (circadian time, CT) for RNA extraction and hybridization on Affymetrix microarrays. Adipocyte-specific Bmal1 KO (Ad-Bmal1-/-) and control mice were used for isolation of tissues at CT0, CT6, CT12, CT18 where CT0 the beginning of the subjective day.
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| Contributor(s) |
Paschos GK, FitzGerald GA |
| Citation(s) |
23142819 |
| Submission date |
Jan 11, 2012 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Georgios K Paschos |
| E-mail(s) |
gpaschos@mail.med.upenn.edu
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| Phone |
215-898-8360
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| Organization name |
University of Pennsylvania, School of Medicine
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| Department |
Pharmacology
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| Lab |
FitzGerald
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| Street address |
10-102 Translational Research Center, 3400 Civic Center Boulevard, Building 421
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (24)
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| GSM860937 |
adipose tissue at CT0, Ad-Bmal1-/- mouse, biological rep1 |
| GSM860938 |
adipose tissue at CT0, control mouse, biological rep1 |
| GSM860939 |
adipose tissue at CT0, Ad-Bmal1-/- mouse, biological rep2 |
| GSM860940 |
adipose tissue at CT0, control mouse, biological rep2 |
| GSM860941 |
adipose tissue at CT0, Ad-Bmal1-/- mouse, biological rep3 |
| GSM860942 |
adipose tissue at CT0, control mouse, biological rep3 |
| GSM860943 |
adipose tissue at CT6, Ad-Bmal1-/- mouse, biological rep1 |
| GSM860944 |
adipose tissue at CT6, control mouse, biological rep1 |
| GSM860945 |
adipose tissue at CT6, Ad-Bmal1-/- mouse, biological rep2 |
| GSM860946 |
adipose tissue at CT6, control mouse, biological rep2 |
| GSM860947 |
adipose tissue at CT6, Ad-Bmal1-/- mouse, biological rep3 |
| GSM860948 |
adipose tissue at CT6, control mouse, biological rep3 |
| GSM860949 |
adipose tissue at CT12, Ad-Bmal1-/- mouse, biological rep1 |
| GSM860950 |
adipose tissue at CT12, control mouse, biological rep1 |
| GSM860951 |
adipose tissue at CT12, Ad-Bmal1-/- mouse, biological rep2 |
| GSM860952 |
adipose tissue at CT12, control mouse, biological rep2 |
| GSM860953 |
adipose tissue at CT12, Ad-Bmal1-/- mouse, biological rep3 |
| GSM860954 |
adipose tissue at CT12, control mouse, biological rep3 |
| GSM860955 |
adipose tissue at CT18, Ad-Bmal1-/- mouse, biological rep1 |
| GSM860956 |
adipose tissue at CT18, control mouse, biological rep1 |
| GSM860957 |
adipose tissue at CT18, Ad-Bmal1-/- mouse, biological rep2 |
| GSM860958 |
adipose tissue at CT18, control mouse, biological rep2 |
| GSM860959 |
adipose tissue at CT18, Ad-Bmal1-/- mouse, biological rep3 |
| GSM860960 |
adipose tissue at CT18, control mouse, biological rep3 |
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| Relations |
| BioProject |
PRJNA151139 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE35026_RAW.tar |
95.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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