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Series GSE2175 Query DataSets for GSE2175
Status Public on May 23, 2005
Title Differential gene expression in pituitary adenomas by oligonucleotide array analysis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This series includes the four major subtypes of pituitary adenomas and normal post-mortem pituitary tissue


Data Transformation
Using Affymetrix Microarray Suite 5.0 global scaling was applied to the quantification data to adjust the average recorded to a target intensity of 100. Data were then exported into the bioinformatics software GeneSpring 6.0 (Silicon Genetics, Redwood City, CA) for further analysis. Data normalization was performed to scale the data so that the average intensity value on each array was 1 by dividing each expression value by the median of the expression levels on each chip. The individual gene expression levels for each of the 4 pituitary adenoma subtype arrays was divided by the expression level in the normal pituitary array. Thus, the data are presented as relative to the expression in normal pituitary tissue. Filtering was then performed to identify genes over-expressed or under-expressed at least 2.0 fold in tumours compared to normal pituitary.


TABLE 1:
The genes / ESTs differentially overexpressed >= 2-fold in at least one pituitary adenoma subtype compared to normal pituitary. Negative values represent underexpression. Where genes are represented by more than one probe set, individual probe data sets are given.


TABLE 2:
The genes / ESTs differentially underexpressed >= 2-fold in at least one pituitary adenoma subtype compared to normal pituitary. Negative values represent underexpression. Where genes are represented by more than one probe set, individual probe data sets are given.


Keywords = pituitary tumor
Keywords: other
 
 
Contributor(s) Morris DG, Musat M, Czirjak S, Hanzely Z, Lillington DM, Korbonits M, Grossman AB
Citation(s) 15994756
Submission date Jan 23, 2005
Last update date Aug 10, 2018
Contact name Damian Morris
E-mail(s) d.morris@qmul.ac.uk
Phone +44 207 601 8343
Organization name St. Bartholomew’s and the Royal London School of Medicine and Dentistry
Department Endocrinology
Lab Endocrine Oncology
Street address
City London
ZIP/Postal code EC1A 7BE
Country United Kingdom
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (5)
GSM38986 normal pituitary
GSM38987 non-functioning pituitary adenoma
GSM38988 ACTH-secreting pituitary adenoma
Relations
BioProject PRJNA91221

TABLE 1: The genes / ESTs differentially overexpressed header descriptions
Probe set ID
Gene name
Gene symbol
Gene locus
NFPA
GH
ACTH
PRL
Genbank

Data table
Probe set ID Gene name Gene symbol Gene locus NFPA GH ACTH PRL Genbank
203504_s_at ATP-binding cassette, sub-family A (ABC1), member 1 ABCA1 9q31.1 -1.748672591 2.12917 1.8713546 1.2082675 NM_005502
203505_at ATP-binding cassette, sub-family A (ABC1), member 1 ABCA1 9q31.1 -2.699558228 1.533064 2.077319 -1.532603456 AF285167.1
212772_s_at ATP-binding cassette, sub-family A (ABC1), member 2 ABCA2 9q34 2.0724962 -1.281022588 1.6728492 2.2840958 AL162060.1
204343_at ATP-binding cassette, sub-family A (ABC1), member 3 ABCA3 16p13.3 2.0355754 -1.255162578 1.5990375 1.0987269 NM_001089
219577_s_at ATP-binding cassette, sub-family A (ABC1), member 7 ABCA7 19p13.3 1.6855016 1.0856695 2.2230241 2.2752516 NM_019112
209993_at ATP-binding cassette, sub-family B (MDR/TAP), member 1 ABCB1 7q21.1 -1.86882752 -1.855894265 1.0414293 2.0625205 AF016535.1
210246_s_at ATP-binding cassette, sub-family C (CFTR/MRP), member 8 ABCC8 11p15.1 1.586771 1.2489705 6.475841 -3.625634921 AF087138.1
201873_s_at ATP-binding cassette, sub-family E (OABP), member 1 ABCE1 4q31 1.1099774 1.1707078 2.1665723 1.4813751 NM_002940
209247_s_at ATP-binding cassette, sub-family F (GCN20), member 2 ABCF2 7q36 1.0657705 -1.658996022 2.8112488 1.3288676 BC001661.1
207622_s_at ATP-binding cassette, sub-family F (GCN20), member 2 ABCF2 7q36 -1.030899299 1.1156996 2.2020931 1.3034825 NM_005692
205566_at abhydrolase domain containing 2 ABHD2 15q26.1 1.1097171 1.6573243 2.097787 1.5082415 NM_007011
212186_at acetyl-Coenzyme A carboxylase alpha ACACA 17q21 3.763533 2.3948166 1.6890851 1.6739867 BE855983
205412_at acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) ACAT1 11q22.3-q23.1 2.1564202 1.2128232 2.5305953 -1.076465198 NM_000019
203839_s_at activated p21cdc42Hs kinase ACK1 3q29 -1.083461651 1.2582588 1.6114719 2.5022924 NM_005781
201128_s_at ATP citrate lyase ACLY 17q12-q21 1.9262667 2.032 1.205748 1.2130519 NM_001096
200793_s_at aconitase 2, mitochondrial ACO2 22q13.2-q13.31 4.6646776 2.1953495 3.6649327 1.9688636 NM_001098
215227_x_at acid phosphatase 1, soluble ACP1 2p25 1.9630479 1.7285011 2.8318987 1.6769419 BG035989
204638_at acid phosphatase 5, tartrate resistant ACP5 19p13.3-p13.2 -3.11321163 -6.535467163 2.070331 -1.104789188 NM_001611
218795_at lysophosphatidic acid phosphatase ACP6 1q21 2.1771667 2.058995 1.4347298 1.5660678 NM_016361
207969_x_at acrosomal vesicle protein 1 ACRV1 11p12-q13 -1.046749289 1.0256798 1.0686604 2.0746522 NM_020109

Total number of rows: 2452

Table truncated, full table size 277 Kbytes.




TABLE 2: The genes / ESTs differentially underexpressed header descriptions
Probe set ID
Gene name
Gene symbol
Gene locus
NFPA
GH
ACTH
PRL
Genbank ID

Data table
Probe set ID Gene name Gene symbol Gene locus NFPA GH ACTH PRL Genbank ID
220953_s_at phosphatidylinositol-3 phosphate 3-phosphatase adaptor subunit 3PAP 5p13.3 -2.032564942 -1.689736641 -1.599973888 -1.685014793 NM_019061
217757_at alpha-2-macroglobulin A2M 12p13.3-p12.3 -1.291043233 -1.60840144 -1.751762102 -2.104754472 NM_000014
219488_at alpha 1,4-galactosyltransferase A4GALT 22q11.2-q13.2 -2.560572782 -2.820429249 1.0926491 1.3743514 NM_017436
202170_s_at aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase AASDHPPT 11q22 -1.04912232 -2.09149277 1.0657251 -2.46768182 AF151057.1
203505_at ATP-binding cassette, sub-family A (ABC1), member 1 ABCA1 9q31.1 -2.699558228 1.533064 2.077319 -1.532603456 AF285167.1
204719_at ATP-binding cassette, sub-family A (ABC1), member 8 ABCA8 17q24 -9.023109447 -1.547806719 -3.392782805 -2.812274227 NM_007168
213485_s_at ATP-binding cassette, sub-family C (CFTR/MRP), member 10 ABCC10 6p21.1 1.374402 -1.135909402 -1.593237281 -2.073816116 AK000002.1
210246_s_at ATP-binding cassette, sub-family C (CFTR/MRP), member 8 ABCC8 11p15.1 1.586771 1.2489705 6.475841 -3.625634921 AF087138.1
202850_at ATP-binding cassette, sub-family D (ALD), member 3 ABCD3 1p22-p21 -1.010642418 -3.169847096 -1.18268693 -2.103778643 NM_002858
207071_s_at aconitase 1, soluble ACO1 9p22-p13 -1.072400584 -2.045976614 -1.141223563 -1.844325637 NM_002197
209600_s_at acyl-Coenzyme A oxidase 1, palmitoyl ACOX1 17q24-17q25 1.1411046 -2.110331419 -1.40987587 -15.69449473 S69189.1
204638_at acid phosphatase 5, tartrate resistant ACP5 19p13.3-p13.2 -3.11321163 -6.535467163 2.070331 -1.104789188 NM_001611
207991_x_at acrosomal vesicle protein 1 ACRV1 11p12-q13 -21.04970811 -6.77232395 -33.96494892 -1.033944501 NM_020113
205132_at actin, alpha, cardiac muscle ACTC 15q11-q14 -1.251405908 -2.1958626 -1.37877576 -1.8639543 NM_005159
213102_at ARP3 actin-related protein 3 homolog (yeast) ACTR3 2q13 1.2731706 -2.463729892 1.2473828 1.2571687 Z78330
205327_s_at activin A receptor, type II ACVR2 2q22.2-q23.3 -2.428469787 -1.766223692 -2.232923234 -1.150148096 NM_001616
207953_at neuronal thread protein AD7C-NTP 1p36 -2.923676718 1.0315076 -1.201767223 -1.103095456 AF010144.1
221128_at a disintegrin and metalloproteinase domain 19 (meltrin beta) ADAM19 5q32-q33 -9.488660813 -1.534881722 -1.458276372 1.0121988 NM_023038
206046_at a disintegrin and metalloproteinase domain 23 ADAM23 2q33 -1.143611927 1.0286555 -3.065692267 -1.012163984 NM_003812
205997_at a disintegrin and metalloproteinase domain 28 ADAM28 8p21.1 -4.104547251 -20.04619686 -1.500768018 -8.474501293 NM_021778

Total number of rows: 2443

Table truncated, full table size 292 Kbytes.




Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE2175_RAW.tar 16.3 Mb (http)(custom) TAR (of CEL, EXP)

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