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| Status |
Public on Mar 10, 2011 |
| Title |
Comparative transcriptome analysis of dedifferentiation in porcine mature adipocytes and follicular granulosa cells |
| Organism |
Sus scrofa |
| Experiment type |
Expression profiling by array
|
| Summary |
Cellular dedifferentiation signifies the withdrawal of cells from a specific differentiated state into a ‘stem cell’-like undifferentiated state. However, the mechanism of dedifferentiation remains obscure. We showed that mature adipocytes (MA) and follicular granulosa cells (GC), which have distinct functions in vivo, can dedifferentiate during culture in vitro and acquire multipotency.
We investigated the dedifferentiation mechanism of MA and GC using global gene expression analyses.
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| Overall design |
Using Affymetrix porcine genome array, we compared global gene expression profiles during dedifferentiation to search for particular biological functions in genes of which expression intensities were increased or decreased by MA and GC dedifferentiation.
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| |
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| Contributor(s) |
Ono H, Oki Y, Bono H, Kano K |
| Citation(s) |
21419102 |
| Submission date |
Jul 22, 2009 |
| Last update date |
May 03, 2013 |
| Contact name |
Hiromasa Ono |
| E-mail(s) |
hono@dbcls.rois.ac.jp
|
| Organization name |
Research Organization of Information and Systems
|
| Department |
Database Center for Life Science (DBCLS)
|
| Lab |
Mishima Lab.
|
| Street address |
National Institute of Genetics, Yata 1111
|
| City |
Mishima |
| State/province |
Shizuoka |
| ZIP/Postal code |
411-8540 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL3533 |
[Porcine] Affymetrix Porcine Genome Array |
|
| Samples (12)
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| Relations |
| BioProject |
PRJNA119169 |
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