|
| Status |
Public on Oct 12, 2020 |
| Title |
Nociceptive nerves regulate haematopoietic stem cell mobilization |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Nociceptive neuropeptide CGRP acts directly on HSCs via the its receptor RAMP1/CALCRL, to promote egress by activating Gαs/Adenylyl cyclase/cAMP pathway.
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| |
|
| Overall design |
mRNA profiles of sorted bone marrow hematopoietic stem cells were generated from Ramp1+/+ and Ramp-/- mice in triplicates by Illumina Platform
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| |
|
| Contributor(s) |
Frenette P, Gao X |
| Citation(s) |
33361809 |
| Submission date |
Aug 19, 2020 |
| Last update date |
Jan 11, 2021 |
| Contact name |
Paul Frenette |
| Organization name |
Albert Einstein College of Medicine
|
| Department |
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research
|
| Lab |
Dr. Frenette
|
| Street address |
1301 Morris Park Avenue , Room 101
|
| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA657999 |
| SRA |
SRP278055 |
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