|
| Status |
Public on Feb 25, 2020 |
| Title |
Nrf2 and HIF1α merge to arsenic-induced metabolic reprogramming and formation of the cancer stem-like cells. |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Arsenic (iAs) induces generation of the cancer stem-like cells (CSCs) through Nrf2-dependent HIF1α activation, and the subsequent metabolic reprogramming from mitochondrial oxdaive phosphorylation to glycolysis in epithelial cells.
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| |
|
| Overall design |
Genome-wide ChIP-seq analysis of the global binding of Nrf2 (sc-13032) and/or HIF1α (ab2185) on the genome in the cells treated with iAs (1 μM for 6 hrs).
|
| |
|
| Contributor(s) |
Chen F, Bi Z |
| Citation(s) |
32226544 |
| Submission date |
Feb 24, 2020 |
| Last update date |
May 26, 2020 |
| Contact name |
Fei Chen |
| E-mail(s) |
fchen@wayne.edu
|
| Organization name |
wayne state university
|
| Department |
Department of Pharmaceutical Sciences
|
| Lab |
Fei Chen
|
| Street address |
4417 Second Ave APT 119
|
| City |
Detroit |
| State/province |
Michigan |
| ZIP/Postal code |
48201 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (5)
|
|
| Relations |
| BioProject |
PRJNA608476 |
| SRA |
SRP250552 |
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