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| Status |
Public on Sep 19, 2022 |
| Title |
Aqp1 overexpression may enhance glioma tumorigenesis by interacting with the transcriptional regulation networks of Foxo4, Maz, and E2F families |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Gliomas is the most common and aggressive primary brain tumor. The C6 glioma cell line has been widely used for decades as experimental model system for the study of glioblastoma growth and invasion. Recently, aquaporin-1 (Aqp1) is reported to facilitate cell migration and potentially involved in tumor progression. Here we overexpressed Aqp1 in C6 cells to examine its potential role in glioblastoma. We found overexpression of Aqp1 in C6 cells significantly increased cell viability and cell migration. The upregulated genes were enriched for cell mobility and glioblastoma. Transcriptional factor binding analysis indicates the upregulated genes were regulated by FOXO4, MAZ, and E2F TF families, which are known factors involved in cell cycle control and cancer progression. Our study suggests Aqp1 is potentially involved in gliomas formation by interacting with the transcriptional regulation networks of FOXO4, MAZ, and E2F TF families.
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| |
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| Overall design |
three treatment (overexpress Aqp1 in C6 cells) vs. three control (no overexpression in C6 cells)
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| |
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| Contributor(s) |
Ying G, Die C, Yuefu Z, Jianqiang C |
| Citation(s) |
38057925 |
| Submission date |
Sep 19, 2019 |
| Last update date |
Dec 14, 2023 |
| Contact name |
Jianqiang Chen |
| E-mail(s) |
yitongchenjq@126.com
|
| Organization name |
Haikou People 's Hospital
|
| Street address |
43 People's Avenue, Meilan District, Haikou City, Hainan Province
|
| City |
Haikou City |
| State/province |
Hainan Province |
| ZIP/Postal code |
570208 |
| Country |
China |
| |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA566414 |
| SRA |
SRP222553 |
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