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Series GSE134556 Query DataSets for GSE134556
Status Public on Aug 26, 2019
Title Endothelial TGFb signaling drives vascular inflammation and atherosclerosis [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Endothelial TGFβ signaling is one of the primary drivers of atherosclerosis-associated vascular inflammation.  Inhibition of endothelial TGFβ signaling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. We performed scRNAseq method to examine endothelial cell gene expression profile using Apoe and EC specific TGFbR1/2 KO in Apoe background mice.
 
Overall design Examination of endothelial cell TGFb signaling downstream transcription factor Smad2/3 in the regulation of inflammatory gene promoters.
 
Contributor(s) Simons M, Chen P
Citation(s) 31572976
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 HL135582 Endothelial-to-mesenchyma transition and atherosclerosis YALE UNIVERSITY Michael Simons
Submission date Jul 19, 2019
Last update date Nov 25, 2019
Contact name Michael Simons
E-mail(s) michael.simons@yale.edu
Organization name Yale University
Department Department: Internal Medicine Cardiology
Lab Yale Cardiovascular Research Center
Street address 3oo George St, Suite 773
City New Haven
State/province CT
ZIP/Postal code 06511
Country USA
 
Platforms (1)
GPL20795 HiSeq X Ten (Homo sapiens)
Samples (16)
GSM3955792 HUVEC PBS Pol II S2
GSM3955793 HUVEC PBS Pol II S5
GSM3955794 HUVEC PBS Smad2
This SubSeries is part of SuperSeries:
GSE134558 Endothelial TGFb signaling drives vascular inflammation and atherosclerosis
Relations
BioProject PRJNA555593
SRA SRP215473

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE134556_RAW.tar 4.1 Gb (http)(custom) TAR (of BIGWIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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