Expression profiling by high throughput sequencing
Summary
Administration of recombinant interferons to 3D brain organoid cultures infected with ZIKV identifies IFN-beta as compound that alleviates organoid damage and inhibits ZIKV
Overall design
Comparison of transcriptomes from ZIKV infected or MOCK organoids treated with IFN-alpha or IFN-beta or left untreated (6 conditions) at two time points