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Series GSE113171 Query DataSets for GSE113171
Status Public on Oct 08, 2018
Title Mapping multi-layered regulation in response to environmental stress
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Other
Summary We have mapped transcript and protein concentrations in cervical cancer cells responding to treatment with tunicamycin over an eight hour time course. We complement this dataset with RNA footprints of ribosomes and non-ribosomal proteins to determine changes in translation and trans-factor binding. The goals of this study are to unveil the time dependent complexity of the signaling pathways at the level of transcription and translation during different stress conditions like stress of the endoplasmic reticulum and oxidative stress.
 
Overall design Hela cells were subjected to ER stress or oxidative stress. Transcript, ribosome footprint and protein occupency profiles were generated for different time points (0, 1 , 4 , and 8 hours) by deep sequencing, in triplicate, using Illumina Illumina HiSeq 2500.
 
Contributor(s) Vogel C, Maity S
Citation(s) 30272558
Submission date Apr 16, 2018
Last update date Mar 27, 2019
Contact name Shuvadeep Maity
E-mail(s) sm6622@nyu.edu, shuvadeep.maity@gmail.com
Organization name New york University
Department Center for Genomics and Systems Biology
Lab Vogel Lab
Street address 12 waverly place
City New York
State/province NY
ZIP/Postal code 10003
Country USA
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (72)
GSM3098446 Total_RNA_Tm_Rep1_0hr
GSM3098447 Total_RNA_Tm_Rep1_1hr
GSM3098448 Total_RNA_Tm_Rep1_4hr
Relations
BioProject PRJNA450369
SRA SRP140470

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113171_RAW.tar 6.9 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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