Severe Acute Respiratory Syndrome (SARS)

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Pre-computed multiple alignment of the coronavirus nsp6-pp1a/pp1ab proteins
NP_828864.1 GKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLV SARS-CoV
NP_840004.1 AG--K-VKSFFYPIMTAMTILFAFWLEFFMYTPFTWINPTFVSIVLAVTTLISTVFVSGI TGEV    
NP_839960.1 GGY---VSRACRNVLLVGSFLTFFWSELVSYTKFFWVNPGYVTPMFACLSLLSSLLMFTL PEDV    
NP_742133.1 SKRTRLVKGIVCWIMASTFLFSCIITAFVKWTMFMYVTT-NMLSITFCALCVISLAMLLV BCoV    
NP_835347.1 SG--K-TTSMFKSISLFAGFFVMFWAELFVYTTTIWVNPGFLTPFMILLVALSLCLTFVV HCoV-229E
NP_740611.1 SKRTRVIKGTCCWILASTFLFCSIISAFVKWTMFMYVTT-HMLGVTLCALCFVSFAMLLI MHV     
NP_740624.1 SSF---VRKATSWFWSR-CVLACFLFVLCAIVLFTAVPLKFYVYAAVILLMAVLFISFTV IBV     
Consensus   u.    lp...p.hh....hh.hhh..hh.ao.F.aVs. .h..h.lhl.hls.hl.h.l


NP_828864.1 KHKHAFLCLFLLPSLATVAYFN---MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYA SARS-CoV
NP_840004.1 KHKMLFFMSFVLPSVILVTAHN----LFWDFSYYESLQSIVENTNTMFLPVDMQGVMLTV TGEV    
NP_839960.1 KHKTLFFQVFLIPALIVTSCIN----LAFDVEVYNYLAEHFD-YHVSLMGFNAQGLVNIF PEDV    
NP_742133.1 KHKHLYLTMYIIPVLFTLLYNNY--LVVYKQTFRGYVYAWLSYYVPSVEYTYTDEVIYGM BCoV    
NP_835347.1 KHKVLFLQVFLLPSIIVAAIQN----CAWDYHVTKVLAEKFD-YNVSVMQMDIQGFVNIF HCoV-229E
NP_740611.1 KHKHLYLTMYIMPVLCTLFYTNY--LVVYKQSFRGLAYAWLSHFVPAVDYTYMDEVLYGV MHV     
NP_740624.1 KHVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLISQVVIFLSQWYDPVVFDTMVPWMFLP IBV     
Consensus   KHK.lahp.allPslhsl.h.N    hhh..ph...lh.bhp h.ssl....hp.hh..h


NP_828864.1 SALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQA---------ISMWALV SARS-CoV
NP_840004.1 FCFIVFVTYSVRFFTCKQSWFSLAVTTILVIFNMVKIFGTSDEPWTENQIAFCFVNMLTM TGEV    
NP_839960.1 VCFVVTILHGTYTWRFFNTPASS-VTYVVALLTAAYNYFYASD----------ILSCAMT PEDV    
NP_742133.1 LLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEE---------ILLMLAS BCoV    
NP_835347.1 ICLFVALLH---TWRFAKERCTHWCTYLFSLIAVLYTALYSYD----------YVSLLVM HCoV-229E
NP_740611.1 VLLVAMVFVTMRSINHDVFSIMFLVGRLVSLVSMWYFGANLEEE---------VLLFLTS MHV     
NP_740624.1 LVLYTAFKCVQGCYMNSFNTSLLMLYQFVKLGFVIYTSSNTLTAYTEGNWELFFELVHTT IBV     
Consensus   hhhhshlb.s..oh..........l..llslh.hhY......p          h..hl..


NP_828864.1 ISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLF SARS-CoV
NP_840004.1 IVSLTTKDWMVVIASYRIAYYIVVCVMP-SAFVSDFGFMKCISIVYMACGYLFCCYYGIL TGEV    
NP_839960.1 LFASVTGNWFVGAVCYKVAVY--MALRF-PTFVAIFGDIKSVMFCYLVLGYFTCCFYGIL PEDV    
NP_742133.1 LFGTYTWT---TALSMAAAKVIAKWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLF BCoV    
NP_835347.1 LLCAISNEWYIGAIIFRICRFG-VAFLP-VEYVSYFDGVKTVLLFYMLLGFVSCMYYGLL HCoV-229E
NP_740611.1 LFGTYTWT---TMLSLATAKVIAKWLAVNVLYFTDVPQIKLVLLSYLCIGYVCCCYWGIL MHV     
NP_740624.1 VLANVSSNSLIGLFVFKCAKWMLYYCNA-----TYLNNYVLMAVMVNCIGWLCTCYFGLY IBV     
Consensus   lhss.o.p   shl.h.hh.h. .hh.. s.hhs.hs.hp.lhlhYhhlGah.oCYaGlh


NP_828864.1 CLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVAT SARS-CoV
NP_840004.1 YWVNRFTCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKIST TGEV    
NP_839960.1 YWFNRFFKVSVGVYDYTVSAAEFKYMVANGLRAPTGTLDSLLLSAKLIGIGGERNIKISS PEDV    
NP_742133.1 SLMNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQ BCoV    
NP_835347.1 YWINRFCKCTLGVYDFCVSPAEFKYMVANGLNAPNGPFDALFLSFKLMGIGGPRTIKVST HCoV-229E
NP_740611.1 SLLNSIFRMPLGVYNYKISVQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQ MHV     
NP_740624.1 WWVNKVFGLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIAT IBV     
Consensus   .hhNphhphslGVYpaplSs.Eh+YMslpsLpsPpssh=lhbLphKLhGIGG..sIclup


NP_828864.1 VQ SARS-CoV
NP_840004.1 VQ TGEV    
NP_839960.1 VQ PEDV    
NP_742133.1 FQ BCoV    
NP_835347.1 VQ HCoV-229E
NP_740611.1 IQ MHV     
NP_740624.1 VQ IBV     
Consensus   lQ                                                         


Similarities are highlighted by colors, if at least 80% of residues in a column are identical or fall into at least one of the following amino acid groups: aromatic (FHWY), aliphatic (ILVA), hydrophobic (ACFILMVWY), alcohol (STC), charged (DEHKR), positive (HKR), negative (DE), polar (CDEHKNQRST), tiny (AGS), small (ACDGNPSTV), or bulky (EFIKLMQRWY). Mouse-over the accession numbers on the left for full protein names or click for a corresponding sequence record. Abbreviated virus names are shown in italics on the right.


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