Severe Acute Respiratory Syndrome (SARS)

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Pre-computed multiple alignment of the coronavirus 3C-like proteinase proteins nsp5-pp1a/pp1ab 
NP_828863.1 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR SARS-CoV
NP_840003.1 SGLRKMAQPSGLVEPCIVRVSYGNNVLNGLWLGDEVICPRHVIASDTTRV-INYENEMSS TGEV    
NP_839959.1 AGLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDIVMCPRHVIASSTTST-IDYDYALSV PEDV    
NP_742132.1 SGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCR BCoV    
NP_835346.1 AGLRKMAQPSGFVEKCVVRVCYGNTVLNGLWLGDIVYCPRHVIASNTTSA-IDYDHEYSI HCoV-229E
NP_740610.1 SGIVKMVSPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSSADMTDPDYPNLLCR MHV     
NP_740623.1 SGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHVLGKFSGDQ---WNDVLNL IBV     
Consensus   uGh.KMlpPou.VE.ClVpVoYGp.sLNGLWLsD.VhCPRHVIhospp.. .pYpp.hp.


NP_828863.1 KSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN SARS-CoV
NP_840003.1 VRLHNFSVSKNN-VFLGVVSARYKGVNLVLKVNQVNPNTPEHKFKSIKAGESFNILACYE TGEV    
NP_839959.1 LRLHNFSISSGN-VFLGVVSATMRGALLQIKVNQNNVHTPKYTYRTVRPGESFNILACYD PEDV    
NP_742132.1 VTSSDFTVLFDR-LSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYN BCoV    
NP_835346.1 MRLHNFSIISGT-AFLGVVGATMHGVTLKIKVSQTNMHTPRHSFRTLKSGEGFNILACYD HCoV-229E
NP_740610.1 VTSSDFCVMSGR-MSLTVMSYQMQGCQLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYN MHV     
NP_740623.1 ANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKYKFIKANCGDSFTIACAYG IBV     
Consensus   hp.ppFpl..sp l.LsVhu.phpGh.L.lpVp..NspTP+apF..lpsG=oFplLAhYp


NP_828863.1 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG SARS-CoV
NP_840003.1 GCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYVLENGILYFVYMHHLELGNGSHVGSNFEG TGEV    
NP_839959.1 GAAAGVYGVNMRSNYTIRGSFINGACGSPGYNINNGTVEFCYLHQLELGSGCHVGSDLDG PEDV    
NP_742132.1 GKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFNG BCoV    
NP_835346.1 GCAQGVFGVNMRTNWTIRGSFINGACGSPGYNLKNGEVEFVYMHQIELGSGSHVGSSFDG HCoV-229E
NP_740610.1 GRPQGAFHVTLRSSHTIKGSFLCGSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSG MHV     
NP_740623.1 GTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLELPNALHTGTDLMG IBV     
Consensus   Gps.Gla.VpMRop.TI+GSFlsGuCGSsGaslp.s.VpFhYMHplELspGsHsGophpG


NP_828863.1 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDR------WFLNRFTTTLNDFNLV SARS-CoV
NP_840003.1 EMYGGYEDQPSMQLEGTNVMSSDNVVAFLYAALINGER------WFVTNTSMSLESYNTW TGEV    
NP_839959.1 VMYGGYEDQPTLQVEGASSLFTENVLAFLYAALINGST------WWLSSSRIAVDRFNEW PEDV    
NP_742132.1 DFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCN------WFVQSDKCSVEDFNVW BCoV    
NP_835346.1 VMYGGFEDQPNLQVESANQMLTVNVVAFLYAAILNGCT------WWLKGEKLFVEHYNEW HCoV-229E
NP_740610.1 NFYGPYRDAQVVQLPVQDYTQTVNVVAWLYAAIFNRCN------WFVQSDSCSLEEFNVW MHV     
NP_740623.1 EFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSLPKWLESTTVSVDDYNKW IBV     
Consensus   .hYGsa.D..slQl.s.p...o.NllAaLYAAllNspp      Walpppphsl=caN.W


NP_828863.1 AMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTP SARS-CoV
NP_840003.1 AKTNSFTELSSTDA--FSMLAAKTGQSVEKLLDSIVR-LNKGFGGRTILSYGSLCDEFTP TGEV    
NP_839959.1 AVHNGMTTVGNTDC--FSILAAKTGVDVQRLLASIQS-LHKNFGGKQILGHTSLTDEFTT PEDV    
NP_742132.1 ALSNGFSQVKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTP BCoV    
NP_835346.1 AQANGFTAMNGEDA--FSILAAKTGVCVERLLHAIQV-LNNGFGGKQILGYSSLNDEFSI HCoV-229E
NP_740610.1 AMTNGFSSIKADLV--LDALASMTGVTVEQVLAAIKR-LHSGFQGKQILGSCVLEDELTP MHV     
NP_740623.1 AGDNGFTPFSTSTA--ITKLSAITGVDVCKLLRTIMV-KNSQWGGDPILGQYNFEDELTP IBV     
Consensus   A.pNuao.hpsp.l  hp.LuubTGlpVpplL.uIb. Lppsa.G+pILG.sshpDEhTs


NP_828863.1 FDVVRQCSGVTFQ SARS-CoV
NP_840003.1 TEVIRQMYGVNLQ TGEV    
NP_839959.1 GEVVRQMYGVNLQ PEDV    
NP_742132.1 SDVYQQLAGIKLQ BCoV    
NP_835346.1 NEVVKQMFGVNLQ HCoV-229E
NP_740610.1 SDVYQQLAGVKLQ MHV     
NP_740623.1 ESVFNQIGGVRLQ IBV     
Consensus   .=VhpQh.GVpLQ

Similarities are highlighted by colors, if at least 80% of residues in a column are identical or fall into at least one of the following amino acid groups: aromatic (FHWY), aliphatic (ILVA), hydrophobic (ACFILMVWY), alcohol (STC), charged (DEHKR), positive (HKR), negative (DE), polar (CDEHKNQRST), tiny (AGS), small (ACDGNPSTV), or bulky (EFIKLMQRWY). Mouse-over the accession numbers on the left for full protein names or click for a corresponding sequence record. Abbreviated virus names are shown in italics on the right.

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