Severe Acute Respiratory Syndrome (SARS)

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Pre-computed multiple alignment of the putative coronavirus ribose 2'-O-methyltransferases nsP16-pp1ab (2'-o-MT) 
NP_828873.2 ASQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNVAKYTQLCQYLNTLTLA SARS-CoV
NP_840013.1 SAE-WNPGYSMPTLYKIQRMCLERCNLYNYGAQVKLPDGITTNVVKYTQLCQYLNTTTLC TGEV    
NP_839969.1 ASE-WKCGYSMPSIYKIQRMCLEPCNLYNYGAGVKLPDGIMFNVVKYTQLCQYLNSTTMC PEDV    
NP_742142.1 AASDWKPGYSMPVLYKYLNSPMERVSLWNYGKPVTLPTGCMMNVAKYTQLCQYLNTTTLA BCoV    
NP_835356.1 SAE-WKCGYSMPGIYKTQRMCLEPCNLYNYGAGLKLPSGIMFNVVKYTQLCQYFNSTTLC HCoV-229E
NP_740620.1 AAADWKPGYVMPVLYKYLESPLERVNLWNYGKPITLPTGCMMNVAKYTQLCQYLSTTTLA MHV     
NP_740633.1 SA--WTCGYNMPELYKVQNCVMEPCNIPNYGVGITLPSGILMNVAKYTQLCQYLSKTTIC IBV     
Consensus   uu. WpsGYsMPslYKhbp.shE.hpLbNYG.slpLPpGhhhNVlKYTQLCQYLpoTTlh


NP_828873.2 VPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHT SARS-CoV
NP_840013.1 VPHKMRVLHLGAAGASGVAPGSTVLRRWLPDDAILVDNDLRDYVSDADFSVTGDCTSLYI TGEV    
NP_839969.1 VPHHMRVLHLGAGSDKGVAPGTAVLRRWLPLDAIIVDNDSVDYVSDADYSVTGDCSTLYL PEDV    
NP_742142.1 VPVNMRVLHLGAGSEKGVAPGSAVLRQWLPAGTILVDNDLYPFVSDSVATYFGDCITLPF BCoV    
NP_835356.1 VPHNMRVLHLGAGSDYGVAPGTAVLKRWLPHDAIVVDNDVVDYVSDADFSVTGDCATVYL HCoV-229E
NP_740620.1 VPANMRVLHLGAGSDKGVAPGSAVLRQWLPAGSILVDNDVNPFVSDSVASYYGNCITLPF MHV     
NP_740633.1 VPHNMRVMHFGAGSDKGVAPGSTVLKQWLPEGTLLVDNDIVDYVSDAHVSVLSDCNKYNT IBV     
Consensus   VP.pMRVlHhGAGS=pGVAPGosVL+pWLP.ssllVDNDl.saVSDushoh.GDC.ol..


NP_828873.2 ANKWDLIISDMYDPRTKHVTKE----NDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSW SARS-CoV
NP_840013.1 EDKFDLLVSDLYDGSTKSIDGE----NTSKDGFFTYINGFIKEKLSLGGSVAIKITEFSW TGEV    
NP_839969.1 SDKFDLVISDMYDGKIKSCDGE----NVSKEGFFPYINGVITEKLALGGTVAIKVTEFSW PEDV    
NP_742142.1 DCQWDLIISDMYDPITKNIGEY----NVSKDGFFTYICHMIRDKLALGGSVAIKITEFSW BCoV    
NP_835356.1 EDKFDLLISDMYDGRTKAIDGE----NVSKEGFFTYINGFICEKLAIGGSIAIKVTEYSW HCoV-229E
NP_740620.1 DCQWDLIISDMYDPLTKNIGEY----NVSKDGFFTYLCHLIRDKLALGGSVAIKITEFSW MHV     
NP_740633.1 EHKFDLVISDMYTDNDSKRKHEGVIANNGNDDVFIYLSSFLRNNLALGGSFAVKVTETSW IBV     
Consensus   pppaDLlISDMYDs.pKphs.b    NsSK=GFFsYlp.hIppKLALGGSlAlKlTEaSW


NP_828873.2 NADLYKLMGHFSWWTAFVTNVNASSSEAFLIGANYLG--KPKEQIDGYTMHANYIFWRNT SARS-CoV
NP_840013.1 NKDLYELIQRFEYWTVFCTSVNTSSSEGFLIGINYLGPYCDKAIVDGNIMHANYIFWRNS TGEV    
NP_839969.1 NKKLYELIQKFEYWTMFCTSVNTSSSEAFLIGVHYLGDFASGAVIDGNTMHANYIFWRNS PEDV    
NP_742142.1 NAELYKLMGYFAFWTVFCTNANASSSEGFLIGINYLG--KPKVEIDGNVMHANYLFWRNS BCoV    
NP_835356.1 NKKLYELVQRFSFWTMFCTSVNTSSSEAFVVGINYLGDFAQGPFIDGNIIHANYVFWRNS HCoV-229E
NP_740620.1 NAELYSLMGKFAFWTIFCTNVNASSSEGFLIGINWLN--KTRTEIDGKTMHANYLFWRNS MHV     
NP_740633.1 HEVLYDIAQDCAWWTMFCTAVNASSSEAFLIGVNYLG-ASEKVKVSGKTLHANYIFWRNC IBV     
Consensus   N.cLYcLh.cF.aWThFCTpVNsSSSEuFLIGlNYLG  ...sblDGp.hHANYlFWRNo


NP_828873.2 NPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDI SARS-CoV
NP_840013.1 TIMALSHNSVLDTPKFKCRCNNALIVNLKEKELNEMVIGLLRKGKLLIRNNGKLLNFGNH TGEV    
NP_839969.1 TIMTMSYNSVLDLSKFNCKHKATVVVNLKDSSISDVVLGLLKNGKLLVRNNDAICGFSNH PEDV    
NP_742142.1 TVWNGGAYSLFDMAKFPLKLAGTAVINLRADQINDMVYSLLEKGKLLVRDTNKEVFVGDS BCoV    
NP_835356.1 TVMSLSYNSVLDLSKFNCKHKATVVVQLKDSDINEMVLSLVRSGKLLVRGNGKCLSFSNH HCoV-229E
NP_740620.1 TMWNGGAYSLFDMSKFPLKAAGTAVVSLKPDQINDLVLSLIEKGKLLVRDTRKEVFVGDS MHV     
NP_740633.1 NYLQTSAYSIFDVAKFDLRLKATPVVNLKTEQKTDLVFNLIKCGKLLVRDVGNTSFTSDS IBV     
Consensus   phhp.u..SlhDhuKFsh+..uTlVlpLK.pplp=hVhuLlcpGKLLlRppsp.h..upp


NP_828873.2 LVNN-- SARS-CoV
NP_840013.1 FVNTP- TGEV    
NP_839969.1 LVNVNK PEDV    
NP_742142.1 LVNVI- BCoV    
NP_835356.1 LVSTK- HCoV-229E
NP_740620.1 LVNVK- MHV     
NP_740633.1 FVCTM- IBV     
Consensus   hVps.

Similarities are highlighted by colors, if at least 80% of residues in a column are identical or fall into at least one of the following amino acid groups: aromatic (FHWY), aliphatic (ILVA), hydrophobic (ACFILMVWY), alcohol (STC), charged (DEHKR), positive (HKR), negative (DE), polar (CDEHKNQRST), tiny (AGS), small (ACDGNPSTV), or bulky (EFIKLMQRWY). Mouse-over the accession numbers on the left for full protein names or click for a corresponding sequence record. Abbreviated virus names are shown in italics on the right.

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