Severe Acute Respiratory Syndrome (SARS)

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Pre-computed multiple alignment of the coronavirus XendoU-like endoRNase proteins nsp15-pp1ab 
NP_828872.1 SLENVAYNVVNKGHFDGHAGEAPVSIINNAVYTKVDGIDVEIFENKTTLPVNVAFELWAK SARS-CoV
NP_840012.1 SLENVAFNVVKKGAFTGLKGDLPTAVIADKIMVRDGPTDKCIFTNKTSLPTNVAFELYAK TGEV    
NP_839968.1 GLENIAFNVLKKGSFVGDEGELPVAVVNDKVLVRDGTVDTLVFTNKTSLPTNVAFELYAK PEDV    
NP_742141.1 SLENVVYNLVKTGHYTGQAGEMPCAIINDKVVAKIDKEDVVIFINNTTYPTNVAVELFAK BCoV    
NP_835355.1 GLENIAFNVVNKGSFVGADGELPVAISGDKVFVRDGNTDNLVFVNKTSLPTNIAFELFAK HCoV-229E
NP_740619.1 SLENVVYNLVNAGHFDGRAGELPCAVIGEKVIAKIQNEDVVVFKNNTPFPTNVAVELFAK MHV     
NP_740632.1 SIDNIAYNMYKGGHYDAIAGEMPTVITGDKVFVIDQGVEKAVFVNQTTLPTSVAFELYAK IBV     
Consensus   uLENllaNllp.GpasG..GEhPsll.s=KVhl+..s.D.hlF.NpTohPTNVAhELaAK


NP_828872.1 RNIKPVPEIKILNNLGVDIAANTVIWDYKREAPAHVSTIGVCTMTDIAKKPTESACSSLT SARS-CoV
NP_840012.1 RKLGLTPPLTILRNLGVVATYKFVLWDYEAERPFSNFTKQVCSYTDLD--------SEVV TGEV    
NP_839968.1 RKVGLTPPITILRNLGVVCTSKCVIWDYEAERPLTTFTKDVCKYTDFE--------GDVC PEDV    
NP_742141.1 RSIRHHPELKLFRNLNIDVCWKHVIWDYARESIFCSNTYGVCMYTDLK------FIDKLN BCoV    
NP_835355.1 RKVGLTPPLSILKNLGVVATYKFVLWDYEAERPLTSFTKSVCGYTDFA--------EDVC HCoV-229E
NP_740619.1 RSIRPHPELKLFRNLNIDVCWSHVLWDYAKDSVFCSSTYKVCKYTDLQ------CIESLN MHV     
NP_740632.1 RNIRTLPNNRILKGLGVDVTNGFVIWDYANQTPLYRNTVKVCAYTDIE-------PNGLV IBV     
Consensus   Rpl...P.lplh+NLslslo.p.VlWDY..=pshpp.Tb.VC.YTDh.        ppls


NP_828872.1 VLFDGRVEGQVDLFRNARNGVLITEGSVKG----LTPSKGPAQASVNG--VTLIGES--- SARS-CoV
NP_840012.1 TCFDNSIAGSFERFTTTRDAVLISNNAVKG----LSAIK-LQYGLLND--LPVSTVGN-- TGEV    
NP_839968.1 TLFDNSIVGSLERFSMTQNAVLMSLTAVKK----LTGIK-LTYGYLNG--VPVNTHED-- PEDV    
NP_742141.1 VLFDGRDNGALEAFKRSNNGVYISTTKVKS----LSMIKGPPRAELNG--VVVDKVGD-- BCoV    
NP_835355.1 TCYDNSIQGSYERFTLSTNAVLFSATAVKTGGKSLPAIK-LNFGMLNGNAIATVKSEDGN HCoV-229E
NP_740619.1 VLFDGRDNGALEAFKKCRNGVYINTTKIKS----LSMIKGPQRADLNG--VVVEKVGD-- MHV     
NP_740632.1 VLYDDR-YGDYQSFLAADNAVLVSTQCYKR----YSYVEIPSNLLVQNG-MPLKDGAN-- IBV     
Consensus   shaDsp..Gsh=.Fp.spNuVhho.p.lK.    Lo.lK ..bu.lNs  lsl.p..p  


NP_828872.1 -VKTQFNYFKKVDG---IIQQLP------------------------------ETYFTQS SARS-CoV
NP_840012.1 -KPVTWYIYVRKNGE--YVEQIDS-------------------------------YYTQG TGEV    
NP_839968.1 -KPFTWYIYTRKNGK--FEDYPDG-------------------------------YFTQG PEDV    
NP_742141.1 -TDCVFYFAVRKEGQDVIFSQFDSLRVSSNQSPQGNLGSNEPGNVGGNDALATSTIFTQS BCoV    
NP_835355.1 IKNINWFVYVRKDGK--PVDHYDG-------------------------------FYTQG HCoV-229E
NP_740619.1 -SDVEFWFAVRKDGDDVIFSRTGSLEPSHYRSPQGNPGGNRVGDLSGNEALARGTIFTQS MHV     
NP_740632.1 -----LYVYKRVNGA--FVTLPNT-------------------------------INTQG IBV     
Consensus    ....aahh.R.pG.  hhpb.ss                               haTQu


NP_828872.1 RDLEDFKPRSQMETDFLELAMDEFIQRYKLEGYAFEHIVYGDFSHGQLGGLHLMIGLAKR SARS-CoV
NP_840012.1 RTFETFKPRSTMEEDFLSMDTTLFIQKYGLEDYGFEHVVFGDVSKTTIGGMHLLISQVRL TGEV    
NP_839968.1 RTTADFSPRSDMEKDFLSMDMGLFINKYGLEDYGFEHVVYGDVSKTTLGGLHLLISQVRL PEDV    
NP_742141.1 RVISSFTCRTDMEKDFIALDQDLFIQKYGLEDYAFEHIVYGNFNQKIIGGLHLLIGLYRR BCoV    
NP_835355.1 RNLQDFLPRSTMEEDFLNMDIGVFIQKYGLEDFNFEHVVYGDVSKTTLGGLHLLISQVRL HCoV-229E
NP_740619.1 RLLSSFTPRSEMEKDFMDLDDDVFIAKYSLQDYAFEHVVYGSFNQKIIGGLHLLIGLARR MHV     
NP_740632.1 RSYETFEPRSDIERDFLAMSEESFVERYG-KDLGLQHILYGEVDKPQLGGLHTVIGMYRL IBV     
Consensus   RshppFpPRSpMEcDFlshp.s.FIp+YuLcDauFEHlVYGphpp..lGGLHLlIubhRb


NP_828872.1 SQDSPLKLEDFIP-MDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIK---SQDLSV SARS-CoV
NP_840012.1 AKMGLFSVQEFMNNSDSTLKSCCITYADDPSSKNVCTYMDILLDDFVTIIK---SLDLNV TGEV    
NP_839968.1 ACMGVLKIDEFVSSNDSTLKSCTVTYADNPSSKMVCTYMDLLLDDFVSILK---SLDLSV PEDV    
NP_742141.1 QQTSNLVIQEFVS-YDSSIHSYFITDEKSGGSKSVCTVIDILLDDFVALVK---SLNLNC BCoV    
NP_835355.1 SKMGILKAEEFVAASDITLKCCTVTYLNDPSSKTVCTYMDLLLDDFVSVLK---SLDLTV HCoV-229E
NP_740619.1 QQKSNLVIQEFVT-YDSSIHSYFITDENSGSSKSVCTVIDLLLDDFVDIVK---SLNLKC MHV     
NP_740632.1 LRANKLNAKSVTN-SDSDVMQNYFVLSDNGSYKQVCTVVDLLLDDFLELLRNILKEYGTN IBV     
Consensus   .p.u.L.lp=Fhs .DSol+ph.lT..ppsSSKpVCThhDlLLDDFVpllK   SbpLph


NP_828872.1 ISKVVKVTIDYAEISFMLWCKDGHVETFYPKLQ SARS-CoV
NP_840012.1 VSKVVDVIVDCKAWRWMLWCENSHIKTFYPQLQ TGEV    
NP_839968.1 VSKVHEVMVDCKMWRWMLWCKDHKLQTFYPQLQ PEDV    
NP_742141.1 VSKVVNVNVDFKDFQFMLWCNDEKVMTFYPRLQ BCoV    
NP_835355.1 VSKVHEVIIDNKPWRWMLWCKDNAVATFYPQLQ HCoV-229E
NP_740619.1 VSKVVNVNVDFKDFQFMLWCNEEKVMTFYPRLQ MHV     
NP_740632.1 KSKVVTVSIDYHSINFMTWFEDGSIKTCYPQLQ IBV     
Consensus   lSKV.pV.lDh+.hpaMLWCp=.plbTFYPpLQ

Similarities are highlighted by colors, if at least 80% of residues in a column are identical or fall into at least one of the following amino acid groups: aromatic (FHWY), aliphatic (ILVA), hydrophobic (ACFILMVWY), alcohol (STC), charged (DEHKR), positive (HKR), negative (DE), polar (CDEHKNQRST), tiny (AGS), small (ACDGNPSTV), or bulky (EFIKLMQRWY). Mouse-over the accession numbers on the left for full protein names or click for a corresponding sequence record. Abbreviated virus names are shown in italics on the right.

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