Severe Acute Respiratory Syndrome (SARS)

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Pre-computed multiple alignment of the coronavirus nuclease ExoN homologs (nsp14-pp1ab) 
NP_828871.1 AENV-TGLFKDCSKIITGLHPTQAPTHLSVDIKFKTEG-LCVDIPGIP-KDMTYRRLISM SARS-CoV
NP_840011.1 AKPETCGLFKDCSKSEQYIPPAYATTYMSLSDNFKTSDGLAVNIG-TK--DVKYANVISY TGEV    
NP_839967.1 ANEG-CGLFKDCSRGDDLLPPSHANTFMSLADNFKTDQYLAVQIGVNG--PIKYEHVISF PEDV    
NP_742140.1 CS---TNLFKDCSKSYSGYHPAHAPSFLAVDDKYKATGDLAVCLGIGD-SAVTYSRLISL BCoV    
NP_835354.1 SESS-CGLFKDCARNPIDLPPSHATTYLSLSDRFKTSGDLAVQIGNNN--VCTYEHVISY HCoV-229E
NP_740618.1 CT---TNLFKDCSRSYVGYHPAHAPSFLAVDDKYKVGGDLAVCLNVAD-SAVTYSRLISL MHV     
NP_740631.1 G----TGLFKICNKEFSGVHPAYAVTTKALAATYKVNDELAALVNVEAGSEITYKHLISL IBV     
Consensus   sp   osLFKDCp+....h.PuaAsoahulsspaKsps.LAVpls..s  shpYp+lISh


NP_828871.1 MGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATRDAVGTNLPLQLGFSTGVNL SARS-CoV
NP_840011.1 MGFRFEANIPGYHTLFCTRDFAMRNVRAWLGFDVEGAHVCGDNVGTNVPLQLGFSNGVDF TGEV    
NP_839967.1 MGFRFDINIPNHHTLFCTRDFAMRNVRGWLGFDVEGAHVVGSNVGTNVPLQLGFSNGVDF PEDV    
NP_742140.1 MGFKLDVTLDGYCKLFITKEEAVKRVRAWVGFDAEGAHATRDSIGTNFPLQLGFSTGIDF BCoV    
NP_835354.1 MGFRFDVSMPGSHSLFCTRDFAMRHVRGWLGMDVEGAHVTGDNVGTNVPLQVGFSNGVDF HCoV-229E
NP_740618.1 MGFKLDLTLDGYCKLFITRDEAIKRVRAWVGFDAEGAHAIRDSIGTNFPLQLGFSTGIDF MHV     
NP_740631.1 LGFKMSVNVEGCHNMFITRDEAIRNVRGWVGFDVEATHACGTNIGTNLPFQVGFSTGADF IBV     
Consensus   MGF+hplplsG.pphFhTR=bAh+pVRuWlGFDlEGhHls.pplGTNhPLQlGFSpGlDF


NP_828871.1 VAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGL SARS-CoV
NP_840011.1 VVQTEGCVITEKGNSIEVVKARAPPGEQFAHLIPLMRKGQPWHIVRRRIVQMVCDYFDGL TGEV    
NP_839967.1 VVRPEGCVVTESGDYIKPVRARAPPGEQFAHLLPLLKRGQPWDVVRKRIVQMCSDYLANL PEDV    
NP_742140.1 VVEATGLFADRDGYSFKKAVAKAPPGEQFKHLIPLMTRGQRWDVVRPRIVQMFADHLIDL BCoV    
NP_835354.1 VAQPEGCVLTNTGSVVKPVRARAPPGEQFTHIVPLLRKGQPWSVLRKRIVQMIADFLAGS HCoV-229E
NP_740618.1 VVEATGMFAERDGYVFKKAAARAPPGEQFKHLIPLMSRGQKWDVVRIRIVQMLSDHLADL MHV     
NP_740631.1 VVTPEGLVDTSIGNNFEPVNSKAPPGEQFNHLRVLFKSAKPWHVIRPRIVQMLADNLCNV IBV     
Consensus   VlpspGhh.pppG..hc.l.A+APPGEQF.HLlPLhp+Gp.WpVlR.RIVQMhuD.L.sl


NP_828871.1 SDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACWNHSVGFDYVY SARS-CoV
NP_840011.1 SDILIFVLWAGGLELTTMRYFVKIGRPQKCE-CGKSATCYSSSQSVYACFKHALGCDYLY TGEV    
NP_839967.1 SDILIFVLWAGGLELTTMRYFVKIGPSKSCD-CGKVATCYNSALHTYCCFKHALGCDYLY PEDV    
NP_742140.1 SDCVVLVTWAANFELTCLRYFAKVGREISCNVCTKRATAYNSRTGYYGCWRHSVTCDYLY BCoV    
NP_835354.1 SDVLVFVLWAGGLELTTMRYFVKIGAVKHCQ-CGTVATCYNSVSNDYCCFKHALGCDYVY HCoV-229E
NP_740618.1 ADSVVLVTWAASFELTCLRYFAKVGREVVCSVCTKRATCFNSRTGYYGCWRHSYSCDYLY MHV     
NP_740631.1 SDCVVFVTWCHGLELTTLRYFVKIGKEQVCS-CGSRATTFNSHTQAYACWKHCLGFDFVY IBV     
Consensus   SD.llhV.WA.uhELTohRYFlKlG..b.Cp Csp.AThapS.p..YsCa+HuluhDYlY


NP_828871.1 NPFMIDVQQWGFTGNLQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSVEYP SARS-CoV
NP_840011.1 NPYCIDIQQWGYTGSLSMNHHEVCNIHRNEHVASGDAIMTRCLAIHDCFVKRVDWSIVYP TGEV    
NP_839967.1 NPYCIDIQQWGYKGSLSLNHHEHCNVHRNEHVASGDAIMTRCLAIHDCFVKNVDWSITYP PEDV    
NP_742140.1 NPLIVDIQQWGYIGSLSSNHDLYCSVHKGAHVASSDAIMTRCLAVYDCFCNNINWNVEYP BCoV    
NP_835354.1 NPYVIDIQQWGYVGSLSTNHHAICNVHRNEHVASGDAIMTRCLAVYDCFVKNVDWSITYP HCoV-229E
NP_740618.1 NPLIVDIQQWGYTGSLTSNHDPICSVHKGAHVASSDAIMTRCLAVHDCFCKSVNWNLEYP MHV     
NP_740631.1 NPLLVDIQQWGYSGNLQFNHDLHCNVHGHAHVASVDAIMTRCLAINNAFCQDVNWDLTYP IBV     
Consensus   NPhhlDIQQWGY.GpLp.NHc..CpVH.s.HVASsDAIMTRCLAla=CFhppVpWplpYP


NP_828871.1 IIGDELRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAIKCVPQAEVEWKFYDAQPCS SARS-CoV
NP_840011.1 FIDNEEKINKAGRIVQSHVMKAALKIFNPAAIHDVGNPKGIRCA-TTPIPWFCYDRDPIN TGEV    
NP_839967.1 FIGNEAVINKSGRIVQSHTMRSVLKLYNPKAIYDIGNPKGIRCA-VTDAKWFCFDKNPTN PEDV    
NP_742140.1 IISNELSINTSCRVLQRVMLKAAMLCNRYTLCYDIGNPKAIACV--KDFDFKFYDAQPIV BCoV    
NP_835354.1 MIANENAINKGGRTVQSHIMRAAIKLYNPKAIHDIGNPKGIRCA-VTDAKWYCYDKNPIN HCoV-229E
NP_740618.1 IISNEVSVNTSCRLLQRVMFRAAMLCNRYDVCYDIGNPKGLACV--KGYDFKFYDASPVV MHV     
NP_740631.1 HIANEDEVNSSCRYLQRMYLNACVDALKVNVVYDIGNPKGIKCVRRGDVNFRFYDKNPIV IBV     
Consensus   hIuNE..lNpusR.lQp.hh+ulhbh.p..lhaDIGNPKuI.Cl  .shpabhYD.pPhs


NP_828871.1 DKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGCDGG SARS-CoV
NP_840011.1 NN---VRCLDYDYMVHG--QMNGLMLFWNCNVDMYPEFSIVCRFDTRTRSKLSLEGCNGG TGEV    
NP_839967.1 SN---VKTLEYDYITHG--QFDGLCLFWNCNVDMYPEFSVVCRFDTRCRSPLNLEGCNGG PEDV    
NP_742140.1 KS---VKTLLYSFEAHKDSFKDGLCMFWNCNVDKYPPNAVVCRFDTRVLNNLNLPGCNGG BCoV    
NP_835354.1 SN---VKTLEYDYMTHG--QMDGLCLFWNCNVDMYPEFSIVCRFDTRTRSTLNLEGVNGG HCoV-229E
NP_740618.1 KS---VKQFVYKYEAHKDQFLDGLCMFWNCNVDKYPANAVVCRFDTRVLNKLNLPGCNGG MHV     
NP_740631.1 RN---VKQFEYDYNQHKDKFADGLCMFWNCNVDCYPDNSLVCRYDTRNLSVFNLPGCNGG IBV     
Consensus   pp   V+ph.YpY.sH.  b.DGLChFWNCNVDbYP..ulVCRFDTRsbp.LNL.GCNGG


NP_828871.1 SLYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRC SARS-CoV
NP_840011.1 ALYVNNHAFHTPAYDRRAFAKLKPMPFFYYDDSNCELVD----GQPNYVPLKSNVCITKC TGEV    
NP_839967.1 SLYVNNHAFHTPAFDKRAFAKLKPMPFFFYDDTECDKLQ----DSINYVPLRASNCITKC PEDV    
NP_742140.1 SLYVNKHAFHTKPFSRAAFEHLKPMPFFYYSDTPCVYMDGMDAKQVDYVPLKSATCITRC BCoV    
NP_835354.1 SLYVNNHAFHTPAYDKRAMAKLKPAPFFYYDDGSCEVVH----DQVNYVPLRATNCITKC HCoV-229E
NP_740618.1 SLYVNKHAFHTSPFTRAAFENLKPMPFFYYSDTPCVYMEGMESKQVDYVPLRSATCITRC MHV     
NP_740631.1 SLYVNKHAFYTPKFDRISFRNLKAMPFFFYDSSPCETIQ-VDGVAQDLVSLATKDCITKC IBV     
Consensus   SLYVNpHAFHTssap+.AF.pLKshPFFaYpDosC..hp    .p.pYVPL+uspCIT+C


NP_828871.1 NLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQFDTYNLWNTFTR---LQ SARS-CoV
NP_840011.1 NIGGAVCKKHAALYRAYVEDYNIFMQAGFTIWCPQNFDTYMLWHGFVNSKALQ TGEV    
NP_839967.1 NVGGAVCSKHCAMYHSYVNAYNTFTSAGFTIWVPTSFDTYNLWQTFSN--NLQ PEDV    
NP_742140.1 NLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTK---LQ BCoV    
NP_835354.1 NIGGAVCSKHANLYRAYVESYNIFTQAGFNIWVPTTFDCYNLWQTFTEV-NLQ HCoV-229E
NP_740618.1 NLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTR---LQ MHV     
NP_740631.1 NIGGAVCKKHAQMYAEFVTSYNAAVTAGFTFWVTNKLNPYNLWKSFSA---LQ IBV     
Consensus   NlGGAVC.KHA.bY+.YlpuYN.h.pAGFohWl.ppFD.YNLWpoFop   LQ

Similarities are highlighted by colors, if at least 80% of residues in a column are identical or fall into at least one of the following amino acid groups: aromatic (FHWY), aliphatic (ILVA), hydrophobic (ACFILMVWY), alcohol (STC), charged (DEHKR), positive (HKR), negative (DE), polar (CDEHKNQRST), tiny (AGS), small (ACDGNPSTV), or bulky (EFIKLMQRWY). Mouse-over the accession numbers on the left for full protein names or click for a corresponding sequence record. Abbreviated virus names are shown in italics on the right.

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