Severe Acute Respiratory Syndrome (SARS)

Genome resources

The Virus
RefSeq genome
RefSeq proteins
All genomes
All nucleotide sequences
Coronaviruses genomes
Nidovirales
References

The Disease
SARS
References

Analysis
DNA alignment graphics
DNA alignment text
SARS proteins
Related structures

Tools
BLAST

Related Resources
CDC SARS
CDC SARS-CoV
WHO SARS
MMWD
SARS Reference

Other Resources
SARS at NLM
CBI at PKU
SARS at EBI
SARS Bioinformatics Suite

SARS Coronavirus

The disease		The virus
In late 2002, an outbreak of severe, atypical pneumonia was reported in Guangdong Province of China. The disease had an extremely high mortality rate (up to 15-19%), and was quickly expanding to other countries. The WHO coined the disease as "severe acute respiratory syndrome", or SARS. More...		In April 2003, a previously unknown coronavirus was isolated from patients and subsequenly proven to be the causative agent according to Koch's postulates in experiments on monkeys. The virus has been named SARS coronavirus (SARS-CoV). More...

This Web resource provides data and information relevant to SARS coronavirus. It includes links to the most recent sequence data and publications, results of pre-computed sequence analysis: genomic, protein, 3D structure. Links are provided to other SARS related resources.

		The genome of SARS-CoV consists of a single giant positive-strand RNA that is approximately 29,700 nucleotides long. View pre-computed global alignment of genomes from various isolates.
Click on the image for a detailed graphical view.

The overall genome organization of SARS-CoV is similar to that of other coronaviruses. Two large overlapping reading frames (ORFs) encompass 71% of the genome. The 3'-adjacent remainder has 12 potential ORFs. These include genes for structural proteins S (spike), E (small envelope), M (membrane), and N (nucleocapsid). Other potential ORFs code for unique putative SARS-CoV-specific polypeptides that lack obvious sequence similarity to known proteins.

A detailed expert analysis of the SARS-CoV genome has been published in J Mol Biol 2003; 331: 991-1004.

Revised: January 8, 2004.