Severe Acute Respiratory Syndrome (SARS)

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Pre-computed multiple alignment of the coronavirus N proteins 
NP_828858.1 ------------MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPN SARS-CoV
NP_598314.1 ------------------------MASVSFQDRG----------------RKRVP----- PEDV    
NP_058428.1 --------------------MANQGQRVSWGDESTKTRGRSNSRGR---KNNNIP----- TGEV    
NP_150083.1 MSFTPGKQSSS-RASSGNRSGNGILK---WADQSDQSRNVQTRGRR-AQPKQTATSQQPS BCoV    
NP_073556.1 ------------------------MATVKWADASEPQRGR----------QGRIP----- HCoV-229E
NP_045302.1 MSFVPGQENAGGRSSSVNRAGNGILKKTTWADQTERGPNNQNRGRR-NQPKQTATTQ-PN MHV     
NP_040838.1 -----------MASGKAAGKTDAPAPVIKLGGPKPPKVGSSGN----------------- IBV     
Consensus                           h...paus.p....s.          p.p.s     


NP_828858.1 NT-----ASWFTALTQHGK-EELRFPRGQGVPINTNSGPDDQIGYYRRATRR-VRGGDGK SARS-CoV
NP_598314.1 -------LSLYAPLRVTNDKPLSKVLANNAVPTNKG-NKDQQIGYWN--EQIRWRMRRGE PEDV    
NP_058428.1 -------LSFFNPITLQQGSKFWNLCPRDFVPKGIG-NRDQQIGYWN--RQTRYRMVKGQ TGEV    
NP_150083.1 GGNVVPYYSWFSGITQFQKGKEFEFAEGQGVPIAPGVPATEAKGYWYRHNRRSFKTADGN BCoV    
NP_073556.1 -------YSLYSPLLVDSEQPW-KVIPRNLVPINKK-DKNKLIGYWN--VQKRFRTRKGK HCoV-229E
NP_045302.1 SGSVVPHYSWFSGITQFQKGKEFQFAEGQGVPIANGIPASEQKGYWYRHNRRSFKTPDGQ MHV     
NP_040838.1 -------ASWFQAIKAKKLNTPPPKFEGSGVPDNENIKPSQQHGYWR--RQARFKPGKGG IBV     
Consensus          hShapslp..p...b.phh..p.VP.s.s s.ppbbGYW.  pp.pa+..cGp


NP_828858.1 MKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNN--AATV SARS-CoV
NP_598314.1 RIEQPSNWHFYYLGTGPHGDLRYRTRTEGVFWVAKEGAKTEPTNLGVRKASEKPIIPKFS PEDV    
NP_058428.1 RKELPERWFFYYLGTGPHADAKFKDKLDGVVWVAKDGAMNKPTTLGSRGANNESKALKFD TGEV    
NP_150083.1 QRQLLPRWYFYYLGTGPHAKDQYGTDIDGVYWVASNQADVNTPADILDRDPSSD--EAIP BCoV    
NP_073556.1 RVDLSPKLHFYYLGTGPHKDAKFRERVEGVVWVAVDGAKTEPTGYGVRRKNSEPEIPHFN HCoV-229E
NP_045302.1 QKQLLPRWYFYYLGTGPHAGASYGDSIEGVFWVANSQADTNTRSDIVERDPSSH--EAIP MHV     
NP_040838.1 RKPVPDAWYFYYTGTGPAADLNWGDTQDGIVWVAAKGADTKSRSNQGTRDPDKF--DQYP IBV     
Consensus   pbpl.spWaFYYLGTGPcuplpa.pp.=GlhWVA.p.A.ppsps..sp+sspp.  ..hs


NP_828858.1 LQLPQGTTLPKGFYAEGSRGGSQASSR----------------SSSRSRGNSR------- SARS-CoV
NP_598314.1 QQLPSVVEIVEPNTPPASRANSRSRSRGNGNNRSRSPSNNRGNNQSRGNSQNRGNNQGRG PEDV    
NP_058428.1 GKVPGEFQLEVN----QSRDNSRSRSQ------------------SRSRSRNR------- TGEV    
NP_150083.1 TRFPPGTVLPQGYYIEGS-GRSAPNSR----------------STSRASSRASS------ BCoV    
NP_073556.1 QKLPNGVTVVEE---PDSRAPSRSQSR----------------SQSRGRGESK------- HCoV-229E
NP_045302.1 TRFAPGTVLPQGFYVEGS-GRSAPASR----------------SGSRSQSRGP------- MHV     
NP_040838.1 LRFSDGGPDGNFRWDFIPLNRGRSGRS----------------TAASSAAASR------- IBV     
Consensus   .phssss.lsp.   ..S s.S.s.Sp                p.SRupupsp       


NP_828858.1 --------------NSTPGSSRGNS-------PARMASGGGETALALLLLDRLNQLESKV SARS-CoV
NP_598314.1 ASQNRGGNNNNNNKSRNQSNNRNQSNDRGGVTSRDDLVAAVKDALKSLGIGENPDRHKQ- PEDV    
NP_058428.1 ------------SQSRGRQQFNNKK--------DDSVEQAVLAALKKLGVDTEKQQQRS- TGEV    
NP_150083.1 ------------AGSRSRANSGNRT-------PTSGVTPDMADQIASLVLAKLGKDAAKP BCoV    
NP_073556.1 ------------PQSRNPSSDRNHN-------SQDDIMKAVAAALKSLGFDKPQEKDKKS HCoV-229E
NP_045302.1 -------------NNRARSSSNQRQ-------PASTVKPDMAEEIAALVLAKLGKDAGQP MHV     
NP_040838.1 --------------APSREGSRGRR---------SDSGDDLIARAAKIIQDQ-------- IBV     
Consensus                 pps..pppspp        .psl..sh.s.l..L.hsp..p...p 


NP_828858.1 SGKGQQQQGQTVTKKSAAEASK------------------KPRQKRTATK--QYNVTQAF SARS-CoV
NP_598314.1 ----QQKPKQEKSDNSGKNTPK---KNKSRATSKERDLKDIPEWRRIPKG--ENSVAACF PEDV    
NP_058428.1 ----RSKSKERSNSKTRDTTPK---------------NENKHTWKRTAGK---GDVTRFY TGEV    
NP_150083.1 -----QQVTKQTAKEIRQKILN------------------KPRQKRSPNK--QCTVQQCF BCoV    
NP_073556.1 AKTGTPKPSRNQSPASSQTSAKSLARSQSSETKEQKHEMQKPRWKRQPNDDVTSNVTQCF HCoV-229E
NP_045302.1 -----KQVTKQSAKEVRQKILN------------------KPRQKRTPNK--QCPVQQCF MHV     
NP_040838.1 -----QKKGSRITKAKADEMAH------------------RRYCKRTIPP--NYRVDQVF IBV     
Consensus        pp..pp.sp...pp..p                  +.pbKRpss.  p.pVpphF


NP_828858.1 GRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTP-------- SARS-CoV
NP_598314.1 GPRGGFK---NFGDAEFVEKGVDASGYAQIASLAPNVAALLFGGNVAVRELA-------- PEDV    
NP_058428.1 GARSSSA---NFGDTDLVANGSSAKHYPQLAECVPSVSSILFGSYWTSKEDG-------- TGEV    
NP_150083.1 GKRGPNQ---NFGGGEMLKLGTSDPQFPILAELAPTAGAFFFGSRLELAKVQNLSGNLDE BCoV    
NP_073556.1 GPRDLDH---NFGSAGVVANGVKAKGYPQFAELVPSTAAMLFDSHIVSKESG-------- HCoV-229E
NP_045302.1 GKRGPNQ---NFGGSEMLKLGTSDPQFPILAELAPTVGAFFFGSKLELVKKN--SGGADE MHV     
NP_040838.1 GPRTKGK-EGNFGDDKMNEEGIKDGRVTAMLNLVPSSHACLFGSRVTPKLQL-------- IBV     
Consensus   G.Rs..p   NFGsschl..Gsps..asbhAphlPosuAhhFsSpl...b..        


NP_828858.1 ---SGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTE-------------PKK SARS-CoV
NP_598314.1 ---DSYEITYNYKMTVPKSDPNVELLVSQVDAFKTGNAKLQRKKE----------KKNKR PEDV    
NP_058428.1 ---DQIEVTFTHKYHLPKDDPKTGQFLQQINAYAR---------------------PSEV TGEV    
NP_150083.1 PQKDVYELRYNGAIRFDSTLSGFETIMKVLNENLNAYQQQDGTMNMSPKPQRQ--RGQKN BCoV    
NP_073556.1 ---NTVVLTFTTRVTVPKDHPHLGKFLEELNAFTR------------------------- HCoV-229E
NP_045302.1 PTKDVYELQYSGAVRFDSTLPGFETIMKVLNENLNAYQKDGGADVVSPKPQRKGRRQAQE MHV     
NP_040838.1 ---DGLHLRFEFTTVVPCDDPQFDNYVKICDQCVDGVGTRPKDDEPKPKS-----RSSSR IBV     
Consensus      psh.lpap..hphspp.P.h.phhp.lp...p                      .p.


NP_828858.1 DKKKKTDEAQPLPQRQKKQPTVTLLPAADMDDFSRQLQNSMSGASADSTQA--------- SARS-CoV
NP_598314.1 ETTLQQHEEAIYDDVGAPSDVTHANLEWDTAVDGGDTAVEIINEIFDTGN---------- PEDV    
NP_058428.1 AKEQRKRKSRSKSAERSEQDVVPDALIENYTDVFDDTQVEIIDEVTN------------- TGEV    
NP_150083.1 GQGENDNISVAAPKSRVQQNKIRELTAEDISLLKKMDEP-----FTEDTSEI-------- BCoV    
NP_073556.1 --EMQQHPLLNPSALEFNPSQTSP-----ATAEPVRDEVSIETDIIDEVN---------- HCoV-229E
NP_045302.1 KKDEVDNVSVAKPKSSVQRNVSRELTPEDRSLLAQILDDGVVPDGLEDDSNV-------- MHV     
NP_040838.1 PATRGNSPAPRQQRPKKEKKLKKQDDEADKALTSDEERNNAQLEFYDEPKVINWGDAALG IBV     
Consensus   ..pb.pp.....s..p.ppp..p.....p.s......ps.h.....=psp          


NP_828858.1 ---- SARS-CoV
NP_598314.1 ---- PEDV    
NP_058428.1 ---- TGEV    
NP_150083.1 ---- BCoV    
NP_073556.1 ---- HCoV-229E
NP_045302.1 ---- MHV     
NP_040838.1 ENEL IBV     
Consensus

Similarities are highlighted by colors, if at least 80% of residues in a column are identical or fall into at least one of the following amino acid groups: aromatic (FHWY), aliphatic (ILVA), hydrophobic (ACFILMVWY), alcohol (STC), charged (DEHKR), positive (HKR), negative (DE), polar (CDEHKNQRST), tiny (AGS), small (ACDGNPSTV), or bulky (EFIKLMQRWY). Mouse-over the accession numbers on the left for full protein names or click for a corresponding sequence record. Abbreviated virus names are shown in italics on the right.

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