Severe Acute Respiratory Syndrome (SARS)

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Pre-computed multiple alignment of the coronavirus M proteins 
NP_828855.1 ---------------------MADNGTIT--------------VEELKQLLEQWNLVIGF SARS-CoV
NP_598313.1 ---------------------MSNGSIP---------------VDEVIEHLRNWNFTWNI PEDV    
NP_058427.2 MKILLILACVIACACGERYCAMKSDTDLSCRNSTASDCESCFNGGDLIWHLANWNFSWSI TGEV    
NP_150082.1 ---------------------MSSVT-TPAPVYTWT-------ADEAIKFLKEWNFSLGI BCoV    
NP_073555.1 ---------------------MSNDNC----------------TGDIVTHLKNWNFGWNV HCoV-229E
NP_045301.1 ---------------------MSSTTQAPEPVYQWT-------ADEAVQFLKEWNFSLGI MHV     
NP_040835.1 ---------------------MPNETNCTLD------------FEQSVQLFKEYNLFITA IBV     
Consensus                        Mspsp..               s.=llp.LcpWNhshsl


NP_828855.1 LFLAWIMLLQFAYSNRNRFLYIIKLVFLWLLWPVTLACFVLA--AVYRIN-WVTGGIAIA SARS-CoV
NP_598313.1 ILTILLVVLQYGHYKYSVFLYGVKMAILWILWPLVLALSLFDAWASFQVN-WVFFAFSIL PEDV    
NP_058427.2 ILIVFITVLQYGRPQFSWFVYGIKMLIMWLLWPVVLALTIFNAYSEYQVSRYVMFGFSIA TGEV    
NP_150082.1 ILLFITVILQFGYTSRSMFVYVIKMVILWLMWPLTIILTIFN--CVYALN-NVYLGFSIV BCoV    
NP_073555.1 ILTIFIVILQFGHYKYSRLFYGLKMLVLWLLWPLVLALSIFDTWANWDSN-WAFVAFSFF HCoV-229E
NP_045301.1 ILLFITIILQFGYTSRSMFIYVVKMIILWLMWPLTIVLCIFN--CVYALN-NVYLGFSIV MHV     
NP_040835.1 FLLFLTIILQYGYATRSKVIYTLKMIVLWCFWPLNIAVGVIS--CTYPPN-TGGLVAAII IBV     
Consensus   lL.hh.hlLQaGa.pbSbhlYslKMllLWlhWPlslllslhp  hsa..N .l.huhuIl


NP_828855.1 MACIVGLMWLSYFVASFRLFARTRSMWSFNPETNILLNVPLR-GTIVTRPLMESELVIGA SARS-CoV
NP_598313.1 MACITLMLWIMYFVNSIRLWRRTHSWWSFNPETDALLTTSVM-GRQVCIPVLGAPTGVTL PEDV    
NP_058427.2 GAIVTFVLWIMYFVRSIQLYRRTKSWWSFNPETKAILCVSAL-GRSYVLPLEGVPTGVTL TGEV    
NP_150082.1 FTIVAIIMWIVYFVNSIRLFIRTGSWWSFNPETNNLMCIDMK-GRMYVRPIIEDYHTLTV BCoV    
NP_073555.1 MAVSTLVMWVMYFANSFRLFRRARTFWAWNPEVNAITVTTVL-GQTYYQPIQQAPTGITV HCoV-229E
NP_045301.1 FTIVSIVIWIMYFVNSIRLFIRTGSWWSFNPETNNLMCIDMK-GTVYVRPIIEDYHTLTA MHV     
NP_040835.1 LTVFACLSFVGYWIQSIRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPMVLSP IBV     
Consensus   hshhshlhWl.YFlpShRLabRo.SaWSFNPEopsl.p.shb Gp.hsbPlb.s..slol


NP_828855.1 VIIRGHLRMAGHSLGR-CDIKDLPKEITVATS-RTLSYYKLGASQRVGTDSG--FAAYNR SARS-CoV
NP_598313.1 TLLSGTLLVEGYKVATGVQVSQLPNFVTVAKATTTIVYGRVGRSVNASSGTG--WAFYVR PEDV    
NP_058427.2 TLLSGNLYAEGFKIAGGMNIDNLPKYVMVALPSRTIVYTLVGKKLKASSATG--WAYYVK TGEV    
NP_150082.1 TIIRGHLYMQGIKLGTGYSLSDLPAYVTVAKVSHLLTYKRG-FLDKIGDTSG--FAVYVK BCoV    
NP_073555.1 TLLSGVLYVDGHRLASGVQVHNLPEYMTVAVPSTTIIYSRVGRSVNSQNSTG--WVFYVR HCoV-229E
NP_045301.1 TIIRGHLYMQGVKLGTGFSLSDLPAYVTVAKVSHLCTYKRA-FLDKVDGVSG--FAVYVK MHV     
NP_040835.1 IIKNGVLYCEGQWLAK-CEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVY IBV     
Consensus   sllpG.LhhpG.plup hplppLP.bl.VA.spp.h.Y.bl b..ps.psoG  aAhYV+


NP_828855.1 YRIGNYKLNTDHAGSNDNIALLVQ-- SARS-CoV
NP_598313.1 SKHGDYSAVSNPSAVLTDSEKVLHLV PEDV    
NP_058427.2 SKAGDYSTEAR-TDNLSEQEKLLHMV TGEV    
NP_150082.1 SKVGNYRLPSTQKGSGLDTALLRNNI BCoV    
NP_073555.1 VKHGDFSAVSSPMSNMTENERLLHFF HCoV-229E
NP_045301.1 SKVGNYRLPSN-KPSGADTALLR--I MHV     
NP_040835.1 AKQSVDTGELESVATGGSSLYT---- IBV     
Consensus   sK.Gpap..sp .sp.spp.bl.

Similarities are highlighted by colors, if at least 80% of residues in a column are identical or fall into at least one of the following amino acid groups: aromatic (FHWY), aliphatic (ILVA), hydrophobic (ACFILMVWY), alcohol (STC), charged (DEHKR), positive (HKR), negative (DE), polar (CDEHKNQRST), tiny (AGS), small (ACDGNPSTV), or bulky (EFIKLMQRWY). Mouse-over the accession numbers on the left for full protein names or click for a corresponding sequence record. Abbreviated virus names are shown in italics on the right.

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