Influenza Virus Resource presents data obtained from the NIAID Influenza Genome Sequencing Project as well as from GenBank,
combined with tools for flu sequence analysis and annotation.
In addition, it provides links to other resources that contain flu sequences,
publications and general information about flu viruses.
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| New features added to the Influenza Virus Resource |
01/30/2008: Phylogenetic trees created by the tree tool can now be exported in the Newick format to be displayed by other tree-viewing programs.
01/03/2008: A manuscript entitled The Influenza Virus Resource at the National Center for
Biotechnology Information is published in Journal of Virology.
10/17/2007: A manuscript entitled The Influenza Virus Resource at the National Center for Biotechnology Information is accepted by the Journal of Virology.
10/05/2007: The signature mutation, E627K, in the PB2 protein (e.g. AY651719) that might confer high virulence of influenza viruses can be detected and reported by the genome annotation tool now.
08/20/2007: An improved multiple sequence alignment tool and a new
version of the tree building tool are
available now. In the multiple sequence alignment result, the anchor/consensus sequence can be displayed for copying.
The printer-friendly output of the multiple sequence alignment shows virus strain names in addition to accession numbers
of the sequences. The tree building tool can take up to 1,000 sequences and has the ability to change the resolutions
of branches of interest on the tree. Sequences on the tree can be searched by the fields in the database, and the resulting sequences or groups will be highlighted.
07/11/2007: A new version of the tree building tool is
available for testing. It can take up to 1000 sequences and has the ability to expand branches of interest on the tree.
06/01/2007: A paper describing the web tool for flu genome annotation is
published online in Nucleic Acids Research.
05/14/2007: An option to remove identical sequences in a dataset is available now.
05/11/2007: Some of the signature mutations that might confer drug resistance by influenza viruses can be detected and reported by the genome annotation tool now. Such mutations include V27A and S31N in the M2 protein, H274Y and R292K in the N1 subtype of neuraminidase, and N294S in the N2 subtype of neuraminidase.
02/08/2007: The genome annotation tool can take multiple sequences
as an input now.
12/22/2006: Full-length nucleotide and protein sequences are flagged in the influenza_na.dat and influenza_aa.dat files in ftp.
11/22/2006: Daily updates of the NCBI Influenza Virus Sequence Database are now available in the "updates" directory through ftp.
10/04/2006: The genomic sequence annotation tool also works for Influenza B viruses now.
06/22/2006: A web tool for flu genomic sequence annotation is now available.
05/12/2006: Genomes of the same virus isolate but sequenced in different labs are now identified and grouped
separately in the database.
04/28/2006: In the multiple sequence alignment of coding regions, non-synonymous changes (in triplets) are now highlighted in a different background color.
04/25/2006: The consensus sequence in the multiple sequence alignment can now be replaced with a sequence of your
choice.
04/19/2006: A nucleotide/protein sequence (e.g. AGCGAAAGCAGGGGT or RSKV) can now be added to the "Search by a string" box to be included
in the database search.
03/28/2006: The multiple sequence alignment is now shown in its intact in a scrollable window, and a printer-friendly version of the
alignment is now available.
03/20/2006: An advanced database search tool is now available.
03/09/2006: In the FASTA sequences downloaded from the database, the following string is inserted between the GenBank sequence identifier and the sequence title in the FASTA definition lines: /host/segment number(name)/subtype/country/year/month/date/.
02/13/2006: A list of GenBank accession numbers for selected protein or nucleotide sequences can now be downloaded from the database.
12/14/2005: Continents have been added to the Country/Region field in the database.
11/17/2005: The new design of the Influenza Virus Resource went to public.
10/19/2005: Data in the NCBI Influenza Virus Sequence Database are now available through ftp.
11/17/2004: The Influenza Virus Resource was first launched.
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