GRC News and Updates
Recently Resolved Mouse Issues
Mouse Genome Overview
Information concerning the continuing improvement of the mouse genome.
Mouse Genome Build 37: A graphical representation of the mouse genome in Build 37. The genome is colored with respect to the genomic component used to build the genome assembly at that location. While >95% of the genome is constructed using HTGS phase 3 (finished) sequence, small bits of unfinished and WGS contribute as well.
The most recent assembly for the mouse is Build 37, which was produced by the Mouse Genome Sequencing Consortium (MGSC). This assembly is based on DNA from a single inbred strain (C57BL/6J) and is largely composed of finished clone sequences. There are, however, 105 unspanned gaps and just over 700 spanned gaps remaining in the assembly. Most of the unspanned gaps result from the inclusion of Whole Genome Shotgun (WGS) contigs in the assembly. The inclusion of this sequence was critical in order to preserve genes not represented in the BAC tiling path. Much of the WGS sequence has been placed on the chromosome, but some remains either unplaced or unlocalized.
The GRC is now actively working to close these gaps. Additionally libraries from C57BL/6J have become available and are being screened in an effort to identify clones that span these gaps. Many of the remaining gaps are associated segmental duplication as described in She et al., 2008. If you know of any remaining issues, please contact us using the links above.