
Reference genome, Community selected, UniProt : Staphylococcus aureus subsp. aureus N315 Staphylococcus aureus subsp. aureus strain N315. This strain is a methicillin-resistant (MRSA) strain isolated in 1982 from a pharyngeal smear of a Japanese patient. Human Pathogen:
yes Biological Properties- Morphology
- Gram : Positive
- Shape : Cocci
- Motility : No
- Environment
- OxygenReq : Facultative
- OptimumTemperature : 30-37
- TemperatureRange : Mesophilic
- Habitat : HostAssociated
- Phenotype
- Disease : Toxic-shock syndrome and staphylococcal scarlet fever

Calculated : Staphylococcus aureus subsp. aureus JH1 Staphylococcus aureus subsp. aureus strain JH1. A series of isogenic methicillin-resistant (MRSA) strains were isolated from a patient undergoing vancomycin treatment. The chronologically earliest strain (JH1) was vancomycin sensitive, while the latest strain (JH9) exhibited increased vancomycin resistance (VISA-type vancomycin resistance). Comparison of these two strains will enable understanding of the evolutionary events that occur under the selective pressure of the presence of antibiotics as well as help explain the genetic basis for vancomycin resistance. Human Pathogen:
yes Biological Properties- Morphology
- Gram : Positive
- Shape : Cocci
- Motility : No
- Environment
- OxygenReq : Facultative
- OptimumTemperature : 30-37
- TemperatureRange : Mesophilic
- Habitat : HostAssociated
- Phenotype
- Disease : Toxic-shock syndrome and staphylococcal scarlet fever
Chromosomes [41] Scaffolds or contigs [391] SRA or Traces [46] No data [73] |
| Organism | BioProject | Assembly | Status | Chrs | Plasmids | Size (Mb) | GC% | Gene | Protein |
|---|
| Staphylococcus aureus subsp. aureus N315 | PRJNA57837, PRJNA264 | ASM964v1 |  | 1 | 1 | 2.84 | 32.8 | 2,695 | 2,614 | | Staphylococcus aureus subsp. aureus JH1 | PRJNA58457, PRJNA15758 | ASM1712v1 |  | 1 | 1 | 2.94 | 33 | 2,906 | 2,780 | | Staphylococcus aureus subsp. aureus TW20 | PRJNA159241, PRJEA36647 | ASM2704v1 |  | 1 | 2 | 3.08 | 32.8 | 2,982 | 2,807 | | Staphylococcus aureus | PRJNA193761, PRJEA71357 | ASM38300v1 |  | 1 | 1 | 2.78 | 32.9 | 2,050 | 1,981 | | Staphylococcus aureus 04-02981 | PRJNA161969, PRJNA34809 | ASM2514v1 |  | 1 | - | 2.82 | 32.9 | 2,732 | 2,650 |
See more...| Other | 1 | | Transcriptome or Gene expression | 107 | | Variation | 10 |
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- Analysis of a novel erm(T)- and cadDX-carrying plasmid from methicillin-susceptible Staphylococcus aureus ST398-t571 of human origin. Gómez-Sanz E, et al. J Antimicrob Chemother 2013 Feb
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- Draft Genome Sequence of the Methicillin-Resistant Staphylococcus aureus Isolate MRSA-M2. Harro JM, et al. Genome Announc 2013 Jan
- Draft Genome Sequences of Four Nosocomial Methicillin-Resistant Staphylococcus aureus (MRSA) Strains (PPUKM-261-2009, PPUKM-332-2009, PPUKM-377-2009, and PPUKM-775-2009) Representative of Dominant MRSA Pulsotypes Circulating in a Malaysian University Teaching Hospital. Neoh HM, et al. Genome Announc 2013 Jan
- Genome sequencing unveils a novel sea enterotoxin-carrying PVL phage in Staphylococcus aureus ST772 from India. Prabhakara S, et al. PLoS One 2013
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- First detection of the staphylococcal trimethoprim resistance gene dfrK and the dfrK-carrying transposon Tn559 in enterococci. López M, et al. Microb Drug Resist 2012 Feb
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- Characteristics and distribution of plasmids in a clonally diverse set of methicillin-resistant Staphylococcus aureus strains. Kuntová L, et al. Arch Microbiol 2012 Jul
- Methicillin-resistant Staphylococcus aureus ST9 from a case of bovine mastitis carries the genes cfr and erm(A) on a small plasmid. Wang XM, et al. J Antimicrob Chemother 2012 May
- Genome sequence of Staphylococcus aureus strain 11819-97, an ST80-IV European community-acquired methicillin-resistant isolate. Stegger M, et al. J Bacteriol 2012 Mar
- Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties. Uhlemann AC, et al. MBio 2012
- Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics. Sass P, et al. J Bacteriol 2012 Apr
- Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus. Cameron DR, et al. J Infect Dis 2012 Jun
- Draft genome sequences of Staphylococcus aureus sequence type 34 (ST34) and ST42 hybrids. Thomas JC, et al. J Bacteriol 2012 May
- Clonal complexes and virulence factors of Staphylococcus aureus from several cities in India. Shambat S, et al. BMC Microbiol 2012 May 1
- Comparative genomics of vancomycin-resistant Staphylococcus aureus strains and their positions within the clade most commonly associated with Methicillin-resistant S. aureus hospital-acquired infection in the United States. Kos VN, et al. MBio 2012
- Unusual small plasmids carrying the novel resistance genes dfrK or apmA isolated from methicillin-resistant or -susceptible staphylococci. Kadlec K, et al. J Antimicrob Chemother 2012 Oct
- Draft genome sequence of Staphylococcus aureus 118 (ST772), a major disease clone from India. Prabhakara S, et al. J Bacteriol 2012 Jul
- Whole-genome sequence of Staphylococcus aureus strain LCT-SA112. Wang J, et al. J Bacteriol 2012 Aug
- Genetic environment and location of the lnu(A) and lnu(B) genes in methicillin-resistant Staphylococcus aureus and other staphylococci of animal and human origin. Lozano C, et al. J Antimicrob Chemother 2012 Dec
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- Genome sequence of Staphylococcus aureus Newbould 305, a strain associated with mild bovine mastitis. Bouchard D, et al. J Bacteriol 2012 Nov
- whole-genome sequence of livestock-associated st398 methicillin-resistant staphylococcus aureus Isolated from Humans in Canada. Golding GR, et al. J Bacteriol 2012 Dec
- Draft genome sequence of Staphylococcus aureus ST672, an emerging disease clone from India. Khedkar S, et al. J Bacteriol 2012 Dec
- Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain. Nair D, et al. J Bacteriol 2011 May
- Genome sequences of two Staphylococcus aureus ovine strains that induce severe (strain O11) and mild (strain O46) mastitis. Le Maréchal C, et al. J Bacteriol 2011 May
- Complete genome sequence of Staphylococcus aureus T0131, an ST239-MRSA-SCCmec type III clone isolated in China. Li Y, et al. J Bacteriol 2011 Jul
- Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. García-Álvarez L, et al. Lancet Infect Dis 2011 Aug
- A very early-branching Staphylococcus aureus lineage lacking the carotenoid pigment staphyloxanthin. Holt DC, et al. Genome Biol Evol 2011
- Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW). Holden MT, et al. J Bacteriol 2010 Feb
- Complete nucleotide sequence and comparative analysis of pPR9, a 41.7-kilobase conjugative staphylococcal multiresistance plasmid conferring high-level mupirocin resistance. Pérez-Roth E, et al. Antimicrob Agents Chemother 2010 May
- A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus. Nübel U, et al. PLoS Pathog 2010 Apr 8
- Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis. Schijffelen MJ, et al. BMC Genomics 2010 Jun 14
- Analysis of the prototypical Staphylococcus aureus multiresistance plasmid pSK1. Jensen SO, et al. Plasmid 2010 Nov
- Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation. Guinane CM, et al. Genome Biol Evol 2010 Jul 12
- Complete genome sequence of Staphylococcus aureus strain JKD6159, a unique Australian clone of ST93-IV community methicillin-resistant Staphylococcus aureus. Chua K, et al. J Bacteriol 2010 Oct
- Complete genome sequence of Staphylococcus aureus strain JKD6008, an ST239 clone of methicillin-resistant Staphylococcus aureus with intermediate-level vancomycin resistance. Howden BP, et al. J Bacteriol 2010 Nov
- Small plasmids carrying vga(A) or vga(C) genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-resistant Staphylococcus aureus ST398 from swine. Kadlec K, et al. J Antimicrob Chemother 2010 Dec
- Complete nucleotide sequence analysis of plasmids in strains of Staphylococcus aureus clone USA300 reveals a high level of identity among isolates with closely related core genome sequences. Kennedy AD, et al. J Clin Microbiol 2010 Dec
- Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. Cui L, et al. Antimicrob Agents Chemother 2009 Mar
- The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. Kenny JG, et al. PLoS One 2009
- Complete nucleotide sequence of pGO1, the prototype conjugative plasmid from the Staphylococci. Caryl JA, et al. Plasmid 2009 Jul
- The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. Voyich JM, et al. J Infect Dis 2009 Jun 1
- Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. Kadlec K, et al. Antimicrob Agents Chemother 2009 Aug
- Mobilization functions of the bacteriocinogenic plasmid pRJ6 of Staphylococcus aureus. Varella Coelho ML, et al. J Microbiol 2009 Jun
- Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections. Vergara-Irigaray M, et al. Infect Immun 2009 Sep
- Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus. Azuma Y, et al. Nucleic Acids Res 2009 Sep
- ALLPATHS 2: small genomes assembled accurately and with high continuity from short paired reads. Maccallum I, et al. Genome Biol 2009
- Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus. Lowder BV, et al. Proc Natl Acad Sci U S A 2009 Nov 17
- Community-acquired methicillin-resistant Staphylococcus aureus pyomyositis with myelitis: A rare occurrence with diverse presentation. Kulkarni GB, et al. Neurol India 2009 Sep-Oct
- Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. Baba T, et al. J Bacteriol 2008 Jan
- Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance. Neoh HM, et al. Antimicrob Agents Chemother 2008 Jan
- First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Mendes RE, et al. Antimicrob Agents Chemother 2008 Jun
- Characterization of the pTZ2162 encoding multidrug efflux gene qacB from Staphylococcus aureus. Nakaminami H, et al. Plasmid 2008 Sep
- Microarray analysis of toxicogenomic effects of ortho-phenylphenol in Staphylococcus aureus. Jang HJ, et al. BMC Genomics 2008 Sep 15
- Genome sequencing and analysis reveals possible determinants of Staphylococcus aureus nasal carriage. Sivaraman K, et al. BMC Genomics 2008 Sep 22
- Analysis of the pSK1 replicon, a prototype from the staphylococcal multiresistance plasmid family. Kwong SM, et al. Microbiology 2008 Oct
- Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. Gentry DR, et al. Antimicrob Agents Chemother 2008 Dec
- Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Mwangi MM, et al. Proc Natl Acad Sci U S A 2007 May 29
- Molecular correlates of host specialization in Staphylococcus aureus. Herron-Olson L, et al. PLoS One 2007 Oct 31
- Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus. Highlander SK, et al. BMC Microbiol 2007 Nov 6
- Analysis of the beta-lactamase plasmid of borderline methicillin-susceptible Staphylococcus aureus: focus on bla complex genes and cadmium resistance determinants cadD and cadX. Massidda O, et al. Plasmid 2006 Mar
- Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin. McAleese F, et al. J Bacteriol 2006 Feb
- Transcription Profiling of the mgrA Regulon in Staphylococcus aureus. Luong TT, et al. J Bacteriol 2006 Mar
- Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Diep BA, et al. Lancet 2006 Mar 4
- Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair. Michel A, et al. J Bacteriol 2006 Aug
- Reporter metabolite analysis of transcriptional profiles of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant displaying the small-colony-variant phenotype. Seggewiss J, et al. J Bacteriol 2006 Nov
- Characterization of the Staphylococcus aureus heat shock, cold shock, stringent, and SOS responses and their effects on log-phase mRNA turnover. Anderson KL, et al. J Bacteriol 2006 Oct
- Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. Gill SR, et al. J Bacteriol 2005 Apr
- Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditions. Resch A, et al. Appl Environ Microbiol 2005 May
- Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315. Ohta T, et al. DNA Res 2004 Feb 29
- An accessory protein is required for relaxosome formation by small staphylococcal plasmids. Smith MC, et al. J Bacteriol 2004 Jun
- Microarray-based analysis of the Staphylococcus aureus sigmaB regulon. Bischoff M, et al. J Bacteriol 2004 Jul
- Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Holden MT, et al. Proc Natl Acad Sci U S A 2004 Jun 29
- Global gene expression in Staphylococcus aureus biofilms. Beenken KE, et al. J Bacteriol 2004 Jul
- Effect of mild acid on gene expression in Staphylococcus aureus. Weinrick B, et al. J Bacteriol 2004 Dec
- Stable low-copy-number Staphylococcus aureus shuttle vectors. Grkovic S, et al. Microbiology 2003 Mar
- A single gene on the staphylococcal multiresistance plasmid pSK1 encodes a novel partitioning system. Simpson AE, et al. J Bacteriol 2003 Apr
- Novel plasmid-borne gene qacJ mediates resistance to quaternary ammonium compounds in equine Staphylococcus aureus, Staphylococcus simulans, and Staphylococcus intermedius. Bjorland J, et al. Antimicrob Agents Chemother 2003 Oct
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- Genetic characterization of the fusidic acid and cadmium resistance determinants of Staphylococcus aureus plasmid pUB101. O'Brien FG, et al. J Antimicrob Chemother 2002 Sep
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- Organization of the antiseptic resistance gene qacA and Tn552-related beta-lactamase genes in multidrug- resistant Staphylococcus haemolyticus strains of animal and human origins. Anthonisen IL, et al. Antimicrob Agents Chemother 2002 Nov
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- Molecular characterisation of aureocin A70, a multi-peptide bacteriocin isolated from Staphylococcus aureus. Netz DJ, et al. J Mol Biol 2001 Aug 31
- Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C. Yamaguchi T, et al. Infect Immun 2001 Dec
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- The staphylococcal insertion sequence IS257 is active. Needham C, et al. Plasmid 1995 Nov
- Characterisation of sin, a potential recombinase-encoding gene from Staphylococcus aureus. Paulsen IT, et al. Gene 1994 Apr 8
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- Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. Rouch DA, et al. Mol Microbiol 1990 Dec
- Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257. Rouch DA, et al. Mol Microbiol 1989 Feb
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- Nucleotide sequence of pS194, a streptomycin-resistance plasmid from Staphylococcus aureus. Projan SJ, et al. Nucleic Acids Res 1988 Mar 25
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