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    alpha-Spec alpha Spectrin [ Tribolium castaneum (red flour beetle) ]

    Gene ID: 662567, updated on 12-Apr-2024

    Summary

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    Gene symbol
    alpha-Spec
    Gene description
    alpha Spectrin
    Locus tag
    TcasGA2_TC000749
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Tribolium castaneum
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_04 current icTriCast1.1 (GCF_031307605.1) 4 NC_087397.1 (8991274..9011864)
    103 previous assembly Tcas5.2 (GCF_000002335.3) Linkage Group LG2 NC_007417.3 (6253386..6274187, complement)

    Chromosome 4 - NC_087397.1Genomic Context describing neighboring genes Neighboring gene brinker Neighboring gene torsin-1A Neighboring gene oocyte zinc finger protein XlCOF28 Neighboring gene Cysteinyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized LOC135265853

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum. Kim HS, et al. Nucleic Acids Res, 2010 Jan. PMID 19820115, Free PMC Article
    2. The genome of the model beetle and pest Tribolium castaneum. Tribolium Genome Sequencing Consortium, et al. Nature, 2008 Apr 24. PMID 18362917

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spectrin alpha chain
    Names
    AUGUSTUS-3.0.2_00749
    GLEAN_00749

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_031307605.1-RS_2024_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference icTriCast1.1 Primary Assembly

    Genomic

    1. NC_087397.1 Reference icTriCast1.1 Primary Assembly

      Range
      8991274..9011864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015985117.2 → XP_015840603.1  spectrin alpha chain isoform X1

      Conserved Domains (6) summary
      cd11808
      Location:976 → 1027
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2291 → 2359
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:1628 → 1832
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:894 → 966
      Spectrin; Spectrin repeat
      pfam08726
      Location:2366 → 2436
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:2294 → 2359
      EF-hand_7; EF-hand domain pair

    2. XM_015985119.2 → XP_015840605.1  spectrin alpha chain isoform X2

      Conserved Domains (6) summary
      cd11808
      Location:976 → 1027
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2283 → 2351
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:1628 → 1832
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:894 → 966
      Spectrin; Spectrin repeat
      pfam08726
      Location:2358 → 2428
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:2286 → 2351
      EF-hand_7; EF-hand domain pair

    3. XM_015985121.2 → XP_015840607.1  spectrin alpha chain isoform X3

      Conserved Domains (6) summary
      cd11808
      Location:976 → 1027
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:2277 → 2345
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:1614 → 1818
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:894 → 966
      Spectrin; Spectrin repeat
      pfam08726
      Location:2352 → 2422
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:2280 → 2345
      EF-hand_7; EF-hand domain pair

    4. XM_064356144.1 → XP_064212214.1  spectrin alpha chain isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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